The Effect of Melatonin on Incretin Hormones: Results From Experimental and Randomized Clinical Studies.
J Clin Endocrinol Metab
; 106(12): e5109-e5123, 2021 11 19.
Article
em En
| MEDLINE
| ID: mdl-34265066
ABSTRACT
CONTEXT Glucose homeostasis is under circadian control through both endocrine and intracellular mechanisms, with several lines of evidence suggesting that melatonin affects glucose homeostasis. OBJECTIVE:
To evaluate the acute in vivo and in situ effects of melatonin on secretion of the incretin hormones, glucagon-like-peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP), and their impact on ß-cell insulin secretion.DESIGN:
A human randomized, double-blinded, placebo-controlled crossover study combined with a confirmatory in situ study of perfused rat intestines.SETTING:
Aarhus University Hospital.METHODS:
Fifteen healthy male participants were examined 2â ×â 2 times an oral glucose tolerance test (OGTT) was performed on day 1 and an isoglycemic IV glucose infusion replicating the blood glucose profile of the OGTT day was performed on day 2. These pairs of study days were repeated on treatment with melatonin and placebo, respectively. For the in situ study, 6 rat intestines and 4 rat pancreases were perfused arterially with perfusion bufferâ ±â melatonin. The intestines were concomitantly perfused with glucose through the luminal compartment.RESULTS:
In humans, melatonin treatment resulted in reduced GIP secretion compared with placebo (ANOVA Pâ =â 0.003), an effect also observed in the perfused rat intestines (ANOVA Pâ =â 0.003), in which GLP-1 secretion also was impaired by arterial melatonin infusion (ANOVA Pâ <â 0.001). Despite a decrease in GIP levels, the in vivo glucose-stimulated insulin secretion was unaffected by melatonin (Pâ =â 0.78).CONCLUSION:
Melatonin reduced GIP secretion during an oral glucose challenge in healthy young men but did not affect insulin secretion. Reduced GIP secretion was confirmed in an in situ model of the rat intestine.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polipeptídeo Inibidor Gástrico
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Células Secretoras de Insulina
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Peptídeo 1 Semelhante ao Glucagon
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Incretinas
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Secreção de Insulina
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Intestinos
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Melatonina
Tipo de estudo:
Clinical_trials
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Observational_studies
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Prognostic_studies
Limite:
Adult
/
Animals
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Humans
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Male
Idioma:
En
Revista:
J Clin Endocrinol Metab
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Dinamarca