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Roles of the tumor suppressor inhibitor of growth family member 4 (ING4) in cancer.
Shatnawi, Aymen; Abu Rabe, Dina I; Frigo, Daniel E.
Afiliação
  • Shatnawi A; Department of Pharmaceutical and Administrative Sciences, University of Charleston School of Pharmacy, Charleston, WV, United States. Electronic address: aymenshatnawi@ucwv.edu.
  • Abu Rabe DI; Integrated Bioscience Program, North Carolina Central University, Durham, NC, United States.
  • Frigo DE; Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, TX, United States; Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Adv Cancer Res ; 152: 225-262, 2021.
Article em En | MEDLINE | ID: mdl-34353439
Inhibitor of growth family member 4 (ING4) is best known as a tumor suppressor that is frequently downregulated, deleted, or mutated in many cancers. ING4 regulates a broad array of tumor-related processes including proliferation, apoptosis, migration, autophagy, invasion, angiogenesis, DNA repair and chromatin remodeling. ING4 alters local chromatin structure by functioning as an epigenetic reader of H3K4 trimethylation histone marks (H3K4Me3) and regulating gene transcription through directing histone acetyltransferase (HAT) and histone deacetylase (HDAC) protein complexes. ING4 may serve as a useful prognostic biomarker for many cancer types and help guide treatment decisions. This review provides an overview of ING4's central functions in gene expression and summarizes current literature on the role of ING4 in cancer and its possible use in therapy.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Supressoras de Tumor / Neoplasias Limite: Humans Idioma: En Revista: Adv Cancer Res Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Supressoras de Tumor / Neoplasias Limite: Humans Idioma: En Revista: Adv Cancer Res Ano de publicação: 2021 Tipo de documento: Article