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Acute Myocarditis and Eculizumab Caused Severe Cholestasis in a 17-Month-Old Child Who Has Hemolytic Uremic Syndrome Associated with Shiga Toxin-Producing Escherichia coli.
Yesilbas, Osman; Yozgat, Can Yilmaz; Akinci, Nurver; Sonmez, Sirin; Tekin, Eser; Talebazadeh, Faraz; Jafarov, Uzeyir; Temur, Hafize Otcu; Yozgat, Yilmaz.
Afiliação
  • Yesilbas O; Department of Pediatric Critical Care Medicine, Bezmialem Vakif University, Istanbul, Turkey.
  • Yozgat CY; Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.
  • Akinci N; Department of Pediatric Nephrology, Bezmialem Vakif University, Istanbul, Turkey.
  • Sonmez S; Department of Pediatrics, Bezmialem Vakif University, Istanbul, Turkey.
  • Tekin E; Department of Pediatrics, Bezmialem Vakif University, Istanbul, Turkey.
  • Talebazadeh F; Department of Pediatrics, Bezmialem Vakif University, Istanbul, Turkey.
  • Jafarov U; Department of Pediatrics, Bezmialem Vakif University, Istanbul, Turkey.
  • Temur HO; Department of Radiology, Bezmialem Vakif University, Istanbul, Turkey.
  • Yozgat Y; Department of Pediatric Cardiology, Bezmialem Vakif University, Istanbul, Turkey.
J Pediatr Intensive Care ; 10(3): 216-220, 2021 Sep.
Article em En | MEDLINE | ID: mdl-34395040
Cardiovascular involvement is uncommon in pediatric patients with hemolytic uremic syndrome associated with Shiga toxin-producing Escherichia coli (STEC-HUS). In this case report we presented a case of 17-month-old toddler who had a sporadic type of STEC-HUS complicated by acute myocarditis. The patient was successfully treated by a single dose of eculizumab after six doses of therapeutic plasma exchange (TPE) were inefficient to prevent the cardiac complication. Hepatotoxicity was observed after a single dose of eculizumab. Hepatic and cholestatic enzyme levels slowly returned to normal within 6 months. To the best of our knowledge, this is the first case of myocarditis/cardiomyopathy treated with eculizumab in STEC-HUS. This case illustrates the need for vigilance regarding myocardial involvement and eculizumab-induced hepatotoxicity in STEC-HUS.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Revista: J Pediatr Intensive Care Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Turquia

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Revista: J Pediatr Intensive Care Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Turquia