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BET bromodomain protein inhibition reverses chimeric antigen receptor extinction and reinvigorates exhausted T cells in chronic lymphocytic leukemia.
Kong, Weimin; Dimitri, Alexander; Wang, Wenliang; Jung, In-Young; Ott, Christopher J; Fasolino, Maria; Wang, Yan; Kulikovskaya, Irina; Gupta, Minnal; Yoder, Todd; DeNizio, Jamie E; Everett, John K; Williams, Erik F; Xu, Jun; Scholler, John; Reich, Tyler J; Bhoj, Vijay G; Haines, Kathleen M; Maus, Marcela V; Melenhorst, J Joseph; Young, Regina M; Jadlowsky, Julie K; Marcucci, Katherine T; Bradner, James E; Levine, Bruce L; Porter, David L; Bushman, Frederic D; Kohli, Rahul M; June, Carl H; Davis, Megan M; Lacey, Simon F; Vahedi, Golnaz; Fraietta, Joseph A.
Afiliação
  • Kong W; Department of Microbiology.
  • Dimitri A; Center for Cellular Immunotherapies.
  • Wang W; Abramson Cancer Center, and.
  • Jung IY; Department of Microbiology.
  • Ott CJ; Center for Cellular Immunotherapies.
  • Fasolino M; Abramson Cancer Center, and.
  • Wang Y; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Kulikovskaya I; Department of Microbiology.
  • Gupta M; Center for Cellular Immunotherapies.
  • Yoder T; Abramson Cancer Center, and.
  • DeNizio JE; Department of Medicine, Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts, USA.
  • Everett JK; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Williams EF; Center for Cellular Immunotherapies.
  • Xu J; Center for Cellular Immunotherapies.
  • Scholler J; Center for Cellular Immunotherapies.
  • Reich TJ; Center for Cellular Immunotherapies.
  • Bhoj VG; Department of Medicine and.
  • Haines KM; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Maus MV; Department of Microbiology.
  • Melenhorst JJ; Department of Microbiology.
  • Young RM; Center for Cellular Immunotherapies.
  • Jadlowsky JK; Abramson Cancer Center, and.
  • Marcucci KT; Center for Cellular Immunotherapies.
  • Bradner JE; Center for Cellular Immunotherapies.
  • Levine BL; Center for Cellular Immunotherapies.
  • Porter DL; Center for Cellular Immunotherapies.
  • Bushman FD; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Kohli RM; Center for Cellular Immunotherapies.
  • June CH; Department of Medicine, Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts, USA.
  • Davis MM; Center for Cellular Immunotherapies.
  • Lacey SF; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Vahedi G; Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Fraietta JA; Center for Cellular Immunotherapies.
J Clin Invest ; 131(16)2021 08 16.
Article em En | MEDLINE | ID: mdl-34396987

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T / Leucemia Linfocítica Crônica de Células B / Proteínas / Imunoterapia Adotiva / Receptores de Antígenos Quiméricos Limite: Humans Idioma: En Revista: J Clin Invest Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T / Leucemia Linfocítica Crônica de Células B / Proteínas / Imunoterapia Adotiva / Receptores de Antígenos Quiméricos Limite: Humans Idioma: En Revista: J Clin Invest Ano de publicação: 2021 Tipo de documento: Article