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Docking and mutagenesis studies lead to improved inhibitor development of ML355 for human platelet 12-lipoxygenase.
Tsai, Wan-Chen; Aleem, Ansari M; Tena, Jennyfer; Rivera-Velazquez, Mirella; Brah, Harman Singh; Tripathi, Sarvind; D'silva, Melinee; Nadler, Jerry L; Kalyanaraman, Chakrapani; Jacobson, Matthew P; Holman, Theodore.
Afiliação
  • Tsai WC; Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, CA 95064, United States.
  • Aleem AM; Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, CA 95064, United States.
  • Tena J; Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, CA 95064, United States.
  • Rivera-Velazquez M; Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, CA 95064, United States.
  • Brah HS; Department of Pharmaceutical Chemistry, School of Pharmacy, University of California San Francisco, San Francisco, CA 94143, United States.
  • Tripathi S; Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, CA 95064, United States.
  • D'silva M; Department of Medicine and Pharmacology, New York Medical College, Valhalla, NY 10595, United States.
  • Nadler JL; Department of Medicine and Pharmacology, New York Medical College, Valhalla, NY 10595, United States.
  • Kalyanaraman C; Department of Pharmaceutical Chemistry, School of Pharmacy, University of California San Francisco, San Francisco, CA 94143, United States.
  • Jacobson MP; Department of Pharmaceutical Chemistry, School of Pharmacy, University of California San Francisco, San Francisco, CA 94143, United States.
  • Holman T; Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, CA 95064, United States. Electronic address: holman@ucsc.edu.
Bioorg Med Chem ; 46: 116347, 2021 09 15.
Article em En | MEDLINE | ID: mdl-34507163
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sulfonamidas / Araquidonato 12-Lipoxigenase / Inibidores de Lipoxigenase / Simulação de Acoplamento Molecular / Desenvolvimento de Medicamentos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sulfonamidas / Araquidonato 12-Lipoxigenase / Inibidores de Lipoxigenase / Simulação de Acoplamento Molecular / Desenvolvimento de Medicamentos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos