Necroptosis activates UPR sensors without disrupting their binding with GRP78.

Liang, Wei; Qi, Weiwei; Geng, Yang; Wang, Linhan; Zhao, Jing; Zhu, Kezhou; Wu, Guowei; Zhang, Zairong; Pan, Heling; Qian, Lihui; Yuan, Junying

Liang, Wei; Qi, Weiwei; Geng, Yang; Wang, Linhan; Zhao, Jing; Zhu, Kezhou; Wu, Guowei; Zhang, Zairong; Pan, Heling; Qian, Lihui; Yuan, Junying.

Afiliação

Liang W; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.
Qi W; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.
Geng Y; University of Chinese Academy of Sciences, Beijing 100049, China.
Wang L; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.
Zhao J; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.
Zhu K; University of Chinese Academy of Sciences, Beijing 100049, China.
Wu G; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.
Zhang Z; University of Chinese Academy of Sciences, Beijing 100049, China.
Pan H; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.
Qian L; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.
Yuan J; University of Chinese Academy of Sciences, Beijing 100049, China.

Proc Natl Acad Sci U S A ; 118(39)2021 09 28.

Article em En | MEDLINE | ID: mdl-34544877

Assuntos

Endorribonucleases/metabolismo; Proteínas de Choque Térmico/metabolismo; Necroptose; Proteínas Serina-Treonina Quinases/metabolismo; Proteína Serina-Treonina Quinases de Interação com Receptores/metabolismo; Resposta a Proteínas não Dobradas; eIF-2 Quinase/metabolismo; Apoptose; Retículo Endoplasmático; Chaperona BiP do Retículo Endoplasmático; Estresse do Retículo Endoplasmático; Endorribonucleases/genética; Células HT29; Proteínas de Choque Térmico/genética; Humanos; Proteínas Serina-Treonina Quinases/genética; Splicing de RNA; Proteína Serina-Treonina Quinases de Interação com Receptores/genética; Proteína 1 de Ligação a X-Box/genética; eIF-2 Quinase/genética

Palavras-chave

ER stress; IRE1α; PERK; UPR sensors; necroptosis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Serina-Treonina Quinases / EIF-2 Quinase / Endorribonucleases / Proteína Serina-Treonina Quinases de Interação com Receptores / Resposta a Proteínas não Dobradas / Necroptose / Proteínas de Choque Térmico Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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