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Using Fractional Anisotropy Imaging to Detect Mild Cognitive Impairment and Alzheimer's Disease among Mexican Americans and Non-Hispanic Whites: A HABLE Study.
Hall, James R; Johnson, Leigh A; Zhang, Fan; Petersen, Melissa; Toga, Arthur W; Shi, Yonggang; Mason, David; Rissman, Robert A; Yaffe, Kristine; O'Bryant, Sid E.
Afiliação
  • Hall JR; Institute for Translational Research, University of North Texas Health Science Center, Fort Worth, Texas, USA.
  • Johnson LA; Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas, USA.
  • Zhang F; Institute for Translational Research, University of North Texas Health Science Center, Fort Worth, Texas, USA.
  • Petersen M; Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas, USA.
  • Toga AW; Institute for Translational Research, University of North Texas Health Science Center, Fort Worth, Texas, USA.
  • Shi Y; Department of Family Medicine, University of North Texas Health Science Center, Fort Worth, Texas, USA.
  • Mason D; Institute for Translational Research, University of North Texas Health Science Center, Fort Worth, Texas, USA.
  • Rissman RA; Department of Family Medicine, University of North Texas Health Science Center, Fort Worth, Texas, USA.
  • Yaffe K; Laboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA.
  • O'Bryant SE; Laboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA.
Dement Geriatr Cogn Disord ; 50(3): 266-273, 2021.
Article em En | MEDLINE | ID: mdl-34569492
ABSTRACT

INTRODUCTION:

Alzheimer's disease (AD) is the most frequently occurring neurodegenerative disease; however, little work has been conducted examining biomarkers of AD among Mexican Americans. Here, we examined diffusion tensor MRI marker profiles for detecting mild cognitive impairment (MCI) and dementia in a multi-ethnic cohort.

METHODS:

3T MRI measures of fractional anisotropy (FA) were examined among 1,636 participants of the ongoing community-based Health & Aging Brain among Latino Elders (HABLE) community-based study (Mexican American n = 851; non-Hispanic white n = 785).

RESULTS:

The FA profile was highly accurate in detecting both MCI (area under the receiver operating characteristic curve [AUC] = 0.99) and dementia (AUC = 0.98). However, the FA profile varied significantly not only between diagnostic groups but also between Mexican Americans and non-Hispanic whites.

CONCLUSION:

Findings suggest that diffusion tensor imaging markers may have a role in the neurodiagnostic process for detecting MCI and dementia among diverse populations.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Neurodegenerativas / Doença de Alzheimer / Disfunção Cognitiva Limite: Aged / Humans País/Região como assunto: Mexico Idioma: En Revista: Dement Geriatr Cogn Disord Assunto da revista: GERIATRIA / NEUROLOGIA / PSIQUIATRIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Neurodegenerativas / Doença de Alzheimer / Disfunção Cognitiva Limite: Aged / Humans País/Região como assunto: Mexico Idioma: En Revista: Dement Geriatr Cogn Disord Assunto da revista: GERIATRIA / NEUROLOGIA / PSIQUIATRIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos