Impact of In Utero Exposure to Antiepileptic Drugs on Neonatal Brain Function.
Cereb Cortex
; 32(11): 2385-2397, 2022 05 31.
Article
em En
| MEDLINE
| ID: mdl-34585721
ABSTRACT
In utero brain development underpins brain health across the lifespan but is vulnerable to physiological and pharmacological perturbation. Here, we show that antiepileptic medication during pregnancy impacts on cortical activity during neonatal sleep, a potent indicator of newborn brain health. These effects are evident in frequency-specific functional brain networks and carry prognostic information for later neurodevelopment. Notably, such effects differ between different antiepileptic drugs that suggest neurodevelopmental adversity from exposure to antiepileptic drugs and not maternal epilepsy per se. This work provides translatable bedside metrics of brain health that are sensitive to the effects of antiepileptic drugs on postnatal neurodevelopment and carry direct prognostic value.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Complicações na Gravidez
/
Efeitos Tardios da Exposição Pré-Natal
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Epilepsia
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Fenômenos Fisiológicos do Sistema Nervoso
Limite:
Female
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Humans
/
Newborn
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Pregnancy
Idioma:
En
Revista:
Cereb Cortex
Assunto da revista:
CEREBRO
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Finlândia