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Molecular hybridization design and synthesis of novel spirooxindole-based MDM2 inhibitors endowed with BCL2 signaling attenuation; a step towards the next generation p53 activators.
Lotfy, Gehad; Abdel Aziz, Yasmine M; Said, Mohamed M; El Ashry, El Sayed H; El Tamany, El Sayed H; Abu-Serie, Marwa M; Teleb, Mohamed; Dömling, Alexander; Barakat, Assem.
Afiliação
  • Lotfy G; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.
  • Abdel Aziz YM; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.
  • Said MM; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.
  • El Ashry ESH; Department of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, Alexandria 21321, Egypt.
  • El Tamany ESH; Department of Chemistry, Faculty of Science, Suez Canal University, Ismailia, Egypt.
  • Abu-Serie MM; Medical Biotechnology Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA-City), Egypt.
  • Teleb M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt.
  • Dömling A; Department of Drug Design, Groningen Research Institute of Pharmacy, University of Groningen, 9713 AV Groningen, the Netherlands.
  • Barakat A; Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia. Electronic address: ambarakat@ksu.edu.sa.
Bioorg Chem ; 117: 105427, 2021 12.
Article em En | MEDLINE | ID: mdl-34794098
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos de Espiro / Proteína Supressora de Tumor p53 / Proteínas Proto-Oncogênicas c-bcl-2 / Proteínas Proto-Oncogênicas c-mdm2 / Oxindóis / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Bioorg Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Egito
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos de Espiro / Proteína Supressora de Tumor p53 / Proteínas Proto-Oncogênicas c-bcl-2 / Proteínas Proto-Oncogênicas c-mdm2 / Oxindóis / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Bioorg Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Egito