Your browser doesn't support javascript.
loading
Novel insights into pivotal risk factors for rectal carriage of extended-spectrum-ß-lactamase-producing enterobacterales within the general population in Lower Saxony, Germany.
Symanzik, Cara; Hillenbrand, Jacqueline; Stasielowicz, Lukasz; Greie, Jörg-Christian; Friedrich, Alex W; Pulz, Matthias; John, Swen Malte; Esser, Jutta.
Afiliação
  • Symanzik C; Institute for Interdisciplinary Dermatological Prevention and Rehabilitation (iDerm) at the Osnabrueck University, Osnabrueck, Germany.
  • Hillenbrand J; Department of Dermatology, Environmental Medicine and Health Theory, Osnabrueck University, Osnabrueck, Germany.
  • Stasielowicz L; Department of Dermatology, Environmental Medicine and Health Theory, Osnabrueck University, Osnabrueck, Germany.
  • Greie JC; Institute of Psychology, Osnabrueck University, Osnabrueck, Germany.
  • Friedrich AW; Department of Dermatology, Environmental Medicine and Health Theory, Osnabrueck University, Osnabrueck, Germany.
  • Pulz M; Laboratory Medical Practice Osnabrueck, Georgsmarienhuette/Osnabrueck, Germany.
  • John SM; Department of Medical Microbiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Esser J; Public Health Agency of Lower Saxony, Hannover, Germany.
J Appl Microbiol ; 132(4): 3256-3264, 2022 Apr.
Article em En | MEDLINE | ID: mdl-34856042
AIMS: To estimate the prevalence of extended-spectrum-ß-lactamase (ESBL)-producing enterobacterales (ESBL-E) carriage in the general population of Lower Saxony, Germany, and to identify risk factors for being colonized. METHODS AND RESULTS: Participants were recruited through local press and information events. Detection of ESBL-E by culture was conducted using ESBL-selective chromagar plates containing third-generation cephalosporins. Identification of pathogens was performed using matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF)_technology on Vitek mass spectrometry. Antibiotic susceptibility testing was conducted by microdilution (Vitek II) and an ESBL confirmation assay was carried out using a combination disk test. Of 527 randomly collected stool samples from healthy volunteers, 5.5% were tested positive for ESBL-E. Post-stratification for age and gender yielded a similar population estimate (5.9%). People traveling abroad and taking antibiotics had the greatest rectal ESBL-E carriage. CONCLUSIONS: Potential risk factors (eg, working in healthcare facilities, recent inpatient stay) did not attribute to rectal ESBL-E carriage as other factors (eg, travelling, taking antibiotics). Rectal ESBL-E carriage within the general population seems to be high. SIGNIFICANCE AND IMPACT OF THE STUDY: The known risk factors for carriage with MDRO might not be fully applicable to ESBL-E and require further examination in order to develop effective strategies for the prevention of ESBL-E dissemination within the general population.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Gammaproteobacteria / Antibacterianos Tipo de estudo: Etiology_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: J Appl Microbiol Assunto da revista: MICROBIOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Alemanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Gammaproteobacteria / Antibacterianos Tipo de estudo: Etiology_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: J Appl Microbiol Assunto da revista: MICROBIOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Alemanha