Disease Prevalence Matters: Challenge for SARS-CoV-2 Testing.
Antibodies (Basel)
; 10(4)2021 Dec 17.
Article
em En
| MEDLINE
| ID: mdl-34940002
ABSTRACT
While sensitivity and specificity are important characteristics for any diagnostic test, the influence of prevalence is equally, if not more, important when such tests are used in community screening. We review the concepts of positive/negative predictive values (PPV/NPV) and how disease prevalence affects false positive/negative rates. In low-prevalence situations, the PPV decreases drastically. We demonstrate how using two tests in an orthogonal fashion can be especially beneficial in low-prevalence settings and greatly improve the PPV of the diagnostic test results.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Antibodies (Basel)
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Singapura