Application of high-throughput transcriptomics for mechanism-based biological read-across of short-chain carboxylic acid analogues of valproic acid.

Vrijenhoek, Nanette G; Wehr, Matthias M; Kunnen, Steven J; Wijaya, Lukas S; Callegaro, Giulia; Moné, Martijn J; Escher, Sylvia E; Van de Water, Bob

Vrijenhoek, Nanette G; Wehr, Matthias M; Kunnen, Steven J; Wijaya, Lukas S; Callegaro, Giulia; Moné, Martijn J; Escher, Sylvia E; Van de Water, Bob.

Afiliação

Vrijenhoek NG; Leiden Academic Centre of Drug Research, Leiden University, The Netherlands.
Wehr MM; ITEM, Fraunhofer Institute, Hannover, Germany.
Kunnen SJ; Leiden Academic Centre of Drug Research, Leiden University, The Netherlands.
Wijaya LS; Leiden Academic Centre of Drug Research, Leiden University, The Netherlands.
Callegaro G; Leiden Academic Centre of Drug Research, Leiden University, The Netherlands.
Moné MJ; Leiden Academic Centre of Drug Research, Leiden University, The Netherlands.
Escher SE; ITEM, Fraunhofer Institute, Hannover, Germany.
Van de Water B; Leiden Academic Centre of Drug Research, Leiden University, The Netherlands.

ALTEX ; 39(2): 207220, 2022.

Article em En | MEDLINE | ID: mdl-35040482

Assuntos

Transcriptoma; Ácido Valproico; Ácidos Carboxílicos/metabolismo; Hepatócitos/metabolismo; Fígado; Ácido Valproico/metabolismo; Ácido Valproico/toxicidade

Palavras-chave

TempO-Seq; Toxicogenomics-MAPr; gene network analysis; liver toxicity; risk assessment

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Valproico / Transcriptoma Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Revista: ALTEX Assunto da revista: MEDICINA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Holanda

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google