Effect of a multi-domain lifestyle intervention on cardiovascular risk in older people: the FINGER trial.
Eur Heart J
; 43(21): 2054-2061, 2022 06 01.
Article
em En
| MEDLINE
| ID: mdl-35051281
ABSTRACT
AIMS:
Joint prevention of cardiovascular disease (CVD) and dementia could reduce the burden of both conditions. The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) demonstrated a beneficial effect on cognition (primary outcome) and we assessed the effect of this lifestyle intervention on incident CVD (pre-specified secondary outcome). METHODS ANDRESULTS:
FINGER enrolled 1259 individuals aged 60-77 years (ClinicalTrials.gov NCT01041989). They were randomized (11) to a 2-year multi-domain intervention with diet, physical and cognitive activity, and vascular monitoring (n = 631), or general health advice (n = 628). National registries provided data on CVD including stroke, transient ischaemic attack (TIA), or coronary heart event. During an average of 7.4 years, 229 participants (18%) had at least one CVD diagnosis 107 in the intervention group and 122 in the control group. The incidence of cerebrovascular events was lower in the intervention than the control group hazard ratio (HR) for combined stroke/TIA was 0.71 [95% confidence interval (CI) 0.51-0.99] after adjusting for background characteristics. Hazard ratio for coronary events was 0.84 (CI 0.56-1.26) and total CVD events 0.80 (95% CI 0.61-1.04). Among those with history of CVD (n = 145), the incidence of both total CVD events (HR 0.50, 95% CI 0.28-0.90) and stroke/TIA (HR 0.40, 95% CI 0.20-0.81) was lower in the intervention than the control group.CONCLUSION:
A 2-year multi-domain lifestyle intervention among older adults was effective in preventing cerebrovascular events and also total CVD events among those who had history of CVD.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Cardiovasculares
/
Ataque Isquêmico Transitório
/
Acidente Vascular Cerebral
Tipo de estudo:
Clinical_trials
/
Etiology_studies
/
Risk_factors_studies
Limite:
Aged
/
Humans
/
Middle aged
Idioma:
En
Revista:
Eur Heart J
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Finlândia