Astragalus mongholicus Bunge-Curcuma aromatica Salisb. suppresses growth and metastasis of colorectal cancer cells by inhibiting M2 macrophage polarization via a Sp1/ZFAS1/miR-153-3p/CCR5 regulatory axis.

Gu, Junfei; Sun, Ruolan; Tang, Decai; Liu, Fuyan; Chang, Xiangwei; Wang, Qiaohan

Gu, Junfei; Sun, Ruolan; Tang, Decai; Liu, Fuyan; Chang, Xiangwei; Wang, Qiaohan.

Afiliação

Gu J; School of Traditional Chinese Medicine and School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, 138# Xianlin Road, Qixia District, Nanjing, 210023, Jiangsu Province, China.
Sun R; School of Traditional Chinese Medicine and School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, 138# Xianlin Road, Qixia District, Nanjing, 210023, Jiangsu Province, China.
Tang D; School of Traditional Chinese Medicine and School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, 138# Xianlin Road, Qixia District, Nanjing, 210023, Jiangsu Province, China.
Liu F; School of Traditional Chinese Medicine and School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, 138# Xianlin Road, Qixia District, Nanjing, 210023, Jiangsu Province, China.
Chang X; School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, China.
Wang Q; School of Traditional Chinese Medicine and School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, 138# Xianlin Road, Qixia District, Nanjing, 210023, Jiangsu Province, China. qhwang83@njucm.edu.cn.

Cell Biol Toxicol ; 38(4): 679-697, 2022 08.

Article em En | MEDLINE | ID: mdl-35072892

Assuntos

Neoplasias Colorretais; Ativação de Macrófagos; Preparações de Plantas; Astragalus propinquus/química; Linhagem Celular Tumoral; Movimento Celular; Proliferação de Células; Neoplasias Colorretais/patologia; Curcuma/química; Humanos; Macrófagos/metabolismo; Macrófagos/patologia; MicroRNAs/genética; Invasividade Neoplásica; Preparações de Plantas/farmacologia; RNA Longo não Codificante/genética; Receptores CCR5/metabolismo; Fator de Transcrição Sp1/metabolismo; Microambiente Tumoral

Palavras-chave

Astragalus mongholicus Bunge-Curcuma aromatica Salisb; CCR5; Colorectal cancer; M2 macrophage polarization; Sp1; ZFAS1; miR-153-3p

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Preparações de Plantas / Ativação de Macrófagos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Cell Biol Toxicol Assunto da revista: TOXICOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

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