Exosome-derived miR-200a promotes esophageal cancer cell proliferation and migration via the mediating Keap1 expression.
Mol Cell Biochem
; 477(4): 1295-1308, 2022 Apr.
Article
em En
| MEDLINE
| ID: mdl-35137328
ABSTRACT
Previous studies have reported that exosomes bearing certain microRNAs (miRNAs) are related to the physiological functions of different types of cancer cells. Our study aimed to elucidate the role of miR-200a in esophageal squamous cell carcinoma (ESCC). We observed that miR-200a expression is higher in esophageal carcinoma cells, tissues, and exosomes than in normal cells and healthy tissues. We showed that exosome-shuttled miR-200a promotes the proliferation, migration, and invasion of esophageal cells and inhibits apoptosis, thereby leading to the progression of ESCC. We showed that miR-200a exerts its effects through its interaction with Keap1, thus altering the Keap1/Nrf2 signaling pathway. Our results suggest that exosome-shuttled miR-200a might be useful as a biomarker for prognosis in patients with ESCC.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
RNA Neoplásico
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Neoplasias Esofágicas
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Regulação Neoplásica da Expressão Gênica
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Movimento Celular
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MicroRNAs
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Proliferação de Células
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Exossomos
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Proteína 1 Associada a ECH Semelhante a Kelch
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Proteínas de Neoplasias
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Mol Cell Biochem
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China