Eosinophils are an essential element of a type 2 immune axis that controls thymus regeneration.
Sci Immunol
; 7(69): eabn3286, 2022 03 11.
Article
em En
| MEDLINE
| ID: mdl-35275754
ABSTRACT
Therapeutic interventions used for cancer treatment provoke thymus damage and limit the recovery of protective immunity. Here, we show that eosinophils are an essential part of an intrathymic type 2 immune network that enables thymus recovery after ablative therapy. Within hours of damage, the thymus undergoes CCR3-dependent colonization by peripheral eosinophils, which reestablishes the epithelial microenvironments that control thymopoiesis. Eosinophil regulation of thymus regeneration occurs via the concerted action of NKT cells that trigger CCL11 production via IL4 receptor signaling in thymic stroma, and ILC2 that represent an intrathymic source of IL5, a cytokine that therapeutically boosts thymus regeneration after damage. Collectively, our findings identify an intrathymic network composed of multiple innate immune cells that restores thymus function during reestablishment of the adaptive immune system.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Regeneração
/
Timo
/
Eosinófilos
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Sci Immunol
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Reino Unido