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Molecular mechanism of microRNAs regulating apoptosis in osteosarcoma.
Cai, Xueyang; Yin, Wei; Tang, Chao; Lu, Yubao; He, Yuqi.
Afiliação
  • Cai X; School of Clinical Medicine, Guizhou Medical University, Guiyang, 550000, Guizhou Province, China.
  • Yin W; School of Clinical Medicine, Guizhou Medical University, Guiyang, 550000, Guizhou Province, China.
  • Tang C; School of Clinical Medicine, Guizhou Medical University, Guiyang, 550000, Guizhou Province, China.
  • Lu Y; Department of Spine Surgery, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510630, Guangdong Province, China.
  • He Y; Trauma Surgery Department, Hannover Medical School (MHH), OE 6230 Carl-Neuberg-Straße 1, 30625, Hanover, Germany. yuqihe46@gmail.com.
Mol Biol Rep ; 49(7): 6945-6956, 2022 Jul.
Article em En | MEDLINE | ID: mdl-35474050
Osteosarcoma is a primary malignant bone tumor with no effective treatment. Apoptosis, one of the programmed cell death, is any pathological form of cell death mediated by intracellular processes. Under the pathological state, the de-regulated regulation of apoptosis can disrupt the balance between cell proliferation and death, causing osteosarcoma proliferation and metastasis. As carcinogenic or tumor suppressor factors, microRNAs (miRNAs) regulate apoptosis of osteosarcoma cells by regulating apoptosis-related genes and apoptosis-related signaling pathways, such as mitochondrial apoptosis pathway, death receptor pathway, and endoplasmic reticulum pathway. Meanwhile as these abnormal miRNAs can be stored and transported by exosomes, detecting exosomes can be seen an effective method to diagnose osteosarcoma in the early stage. This review provides the current knowledge of miRNAs and their target genes related to the apoptosis of osteosarcoma, summarizes abnormal expression and regulation of miRNAs and signaling pathways in osteosarcoma and prospects the detection of exosome as a method for early diagnosis of osteosarcoma.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ósseas / Osteossarcoma / MicroRNAs Tipo de estudo: Screening_studies Limite: Humans Idioma: En Revista: Mol Biol Rep Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ósseas / Osteossarcoma / MicroRNAs Tipo de estudo: Screening_studies Limite: Humans Idioma: En Revista: Mol Biol Rep Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China