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Regulation and role of CAMKK2 in prostate cancer.
Pulliam, Thomas L; Goli, Pavithr; Awad, Dominik; Lin, Chenchu; Wilkenfeld, Sandi R; Frigo, Daniel E.
Afiliação
  • Pulliam TL; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Goli P; Center for Nuclear Receptors and Cell Signalling, University of Houston, Houston, TX, USA.
  • Awad D; Department of Biology and Biochemistry, University of Houston, Houston, TX, USA.
  • Lin C; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Wilkenfeld SR; Rice University, Houston, TX, USA.
  • Frigo DE; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Nat Rev Urol ; 19(6): 367-380, 2022 06.
Article em En | MEDLINE | ID: mdl-35474107
In 2011, CAMKK2, the gene encoding calcium/calmodulin-dependent kinase kinase 2 (CAMKK2), was demonstrated to be a direct target of the androgen receptor and a driver of prostate cancer progression. Results from multiple independent studies have confirmed these findings and demonstrated the potential role of CAMKK2 as a clinical biomarker and therapeutic target in advanced prostate cancer using a variety of preclinical models. Drug development efforts targeting CAMKK2 have begun accordingly. CAMKK2 regulation can vary across disease stages, which might have important implications in the use of CAMKK2 as a biomarker. Moreover, new non-cell-autonomous roles for CAMKK2 that could affect tumorigenesis, metastasis and possible comorbidities linked to disease and treatment have emerged and could present novel treatment opportunities for prostate cancer.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Quinase da Proteína Quinase Dependente de Cálcio-Calmodulina Tipo de estudo: Prognostic_studies Limite: Humans / Male Idioma: En Revista: Nat Rev Urol Assunto da revista: UROLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Quinase da Proteína Quinase Dependente de Cálcio-Calmodulina Tipo de estudo: Prognostic_studies Limite: Humans / Male Idioma: En Revista: Nat Rev Urol Assunto da revista: UROLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos