Neurodevelopmental Outcome of Extremely Low Birth Weight Infants with Cholestasis at 12 and 24 Months.
Neonatology
; 119(4): 501-509, 2022.
Article
em En
| MEDLINE
| ID: mdl-35679842
ABSTRACT
INTRODUCTION:
The aims of the study were to describe the neurodevelopmental outcome of extremely low birth weight (ELBW) infants with parenteral nutrition-associated cholestasis (PNAC) and to assess whether PNAC is associated with adverse neurodevelopmental outcome.METHODS:
The study is a secondary analysis of controlled trial (June 2012-October 2017) on PNAC incidence in ELBW infants receiving two different parenteral lipid emulsions (mixed lipid emulsion containing fish oil vs. soybean oil-based). Neurodevelopmental follow-up at 12- and 24-month corrected age was compared in infants with and without PNAC. A machine learning-based regression analysis was used to assess whether PNAC was associated with adverse neurodevelopmental outcome.RESULTS:
For assessment of neurodevelopmental outcome (Bayley-III), 174 infants were available at 12-month (PNAC n = 21; no PNAC n = 153) and 164 infants at 24-month (PNAC n = 20; no PNAC n = 144) corrected age. The neurodevelopment of ELBW infants with PNAC was globally delayed, with significantly lower cognitive, language, and motor scores at both 12- and 24-month corrected age. Regression analyses revealed that PNAC was associated with an adverse motor outcome.CONCLUSION:
ELBW infants with PNAC are at increased risk for adverse neurodevelopmental outcome.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Colestase
/
Recém-Nascido de Peso Extremamente Baixo ao Nascer
Tipo de estudo:
Clinical_trials
/
Etiology_studies
Limite:
Humans
/
Newborn
Idioma:
En
Revista:
Neonatology
Assunto da revista:
PERINATOLOGIA
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Áustria