Sequential Stem Cell-Kidney Transplantation in Schimke Immuno-osseous Dysplasia.
N Engl J Med
; 386(24): 2295-2302, 2022 06 16.
Article
em En
| MEDLINE
| ID: mdl-35704481
ABSTRACT
Lifelong immunosuppression is required for allograft survival after kidney transplantation but may not ultimately prevent allograft loss resulting from chronic rejection. We developed an approach that attempts to abrogate immune rejection and the need for post-transplantation immunosuppression in three patients with Schimke immuno-osseous dysplasia who had both T-cell immunodeficiency and renal failure. Each patient received sequential transplants of αß T-cell-depleted and CD19 B-cell-depleted haploidentical hematopoietic stem cells and a kidney from the same donor. Full donor hematopoietic chimerism and functional ex vivo T-cell tolerance was achieved, and the patients continued to have normal renal function without immunosuppression at 22 to 34 months after kidney transplantation. (Funded by the Kruzn for a Kure Foundation.).
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteocondrodisplasias
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Transplante de Rim
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Transplante de Células-Tronco Hematopoéticas
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Doenças da Imunodeficiência Primária
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Síndromes de Imunodeficiência
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Síndrome Nefrótica
Limite:
Humans
Idioma:
En
Revista:
N Engl J Med
Ano de publicação:
2022
Tipo de documento:
Article