Brain pharmacokinetics and metabolism of the AMP-activated protein kinase selective inhibitor SBI-0206965, an investigational agent for the treatment of glioblastoma.

Desai, Janki M; Karve, Aniruddha S; Gudelsky, Gary A; Gawali, Mruniya V; Seibel, William; Sallans, Larry; DasGupta, Biplab; Desai, Pankaj B

Desai, Janki M; Karve, Aniruddha S; Gudelsky, Gary A; Gawali, Mruniya V; Seibel, William; Sallans, Larry; DasGupta, Biplab; Desai, Pankaj B.

Afiliação

Desai JM; Division of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH, USA.
Karve AS; Division of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH, USA.
Gudelsky GA; Division of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH, USA.
Gawali MV; Center for Immunotherapy and Precision Immuno-Oncology (CITI), Lerner Research Institute - Cleveland Clinic, Cleveland, OH, USA.
Seibel W; Division of Oncology, Cincinnati Children's Hospital, Cincinnati, OH, USA.
Sallans L; R. Marshall Wilson Mass Spectrometry Facility, Rieveschl Laboratories for Mass Spectrometry, Department of Chemistry, College of Arts and Sciences, University of Cincinnati, Cincinnati, OH, USA.
DasGupta B; Division of Oncology, Cincinnati Children's Hospital, Cincinnati, OH, USA.
Desai PB; Division of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH, USA. Pankaj.Desai@uc.edu.

Invest New Drugs ; 40(5): 944-952, 2022 Oct.

Article em En | MEDLINE | ID: mdl-35802287

Assuntos

Neoplasias Encefálicas; Glioblastoma; Proteínas Quinases Ativadas por AMP/metabolismo; Animais; Benzamidas; Encéfalo/metabolismo; Neoplasias Encefálicas/tratamento farmacológico; Neoplasias Encefálicas/metabolismo; Drogas em Investigação; Glioblastoma/tratamento farmacológico; Glioblastoma/metabolismo; Humanos; Camundongos; Camundongos Endogâmicos C57BL; Pirimidinas; Ratos

Palavras-chave

5' Adenosine Monophosphate-Activated Protein Kinase; Brain partitioning; Glioblastoma; In-vitro metabolism

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Glioblastoma Limite: Animals / Humans Idioma: En Revista: Invest New Drugs Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

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