Targeting HER3-dependent activation of nuclear AKT improves radiotherapy of non-small cell lung cancer.

Toulany, Mahmoud; Iida, Mari; Lettau, Konstanze; Coan, John P; Rebholz, Simone; Khozooei, Shayan; Harari, Paul M; Wheeler, Deric L

Toulany, Mahmoud; Iida, Mari; Lettau, Konstanze; Coan, John P; Rebholz, Simone; Khozooei, Shayan; Harari, Paul M; Wheeler, Deric L.

Afiliação

Toulany M; Division of Radiobiology and Molecular Environmental Research, Department of Radation Oncology, University of Tuebingen, Tuebingen, Germany; German Cancer Consortium (DKTK), Partner Site Tuebingen, German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address: mahmoud.toulany@uni-tue
Iida M; Department of Human Oncology, University of Wisconsin, Madison, WI, USA.
Lettau K; Division of Radiobiology and Molecular Environmental Research, Department of Radation Oncology, University of Tuebingen, Tuebingen, Germany.
Coan JP; Department of Human Oncology, University of Wisconsin, Madison, WI, USA.
Rebholz S; Division of Radiobiology and Molecular Environmental Research, Department of Radation Oncology, University of Tuebingen, Tuebingen, Germany.
Khozooei S; Division of Radiobiology and Molecular Environmental Research, Department of Radation Oncology, University of Tuebingen, Tuebingen, Germany.
Harari PM; Department of Human Oncology, University of Wisconsin, Madison, WI, USA.
Wheeler DL; Department of Human Oncology, University of Wisconsin, Madison, WI, USA.

Radiother Oncol ; 174: 92-100, 2022 09.

Article em En | MEDLINE | ID: mdl-35839938

Assuntos

Carcinoma Pulmonar de Células não Pequenas; Neoplasias Pulmonares; Animais; Anticorpos Neutralizantes/genética; Carcinoma Pulmonar de Células não Pequenas/genética; Linhagem Celular Tumoral; Quebras de DNA de Cadeia Dupla; Reparo do DNA; Receptores ErbB/genética; Humanos; Neoplasias Pulmonares/metabolismo; Neoplasias Pulmonares/radioterapia; Camundongos; Proteínas Proto-Oncogênicas c-akt/genética; Proteínas Proto-Oncogênicas c-akt/metabolismo; RNA Interferente Pequeno

Palavras-chave

DNA repair; HER3; Non-small cell lung cancer; Nuclear AKT; Radioresistance

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Radiother Oncol Ano de publicação: 2022 Tipo de documento: Article

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