Kinetics of Surface Enrichment of a Polymer in a Glass-Forming Molecular Liquid.

Yu, Junguang; Yao, Xin; Que, Chailu; Huang, Lian; Hui, Ho-Wah; Gong, Yuchuan; Qian, Feng; Yu, Lian

Yu, Junguang; Yao, Xin; Que, Chailu; Huang, Lian; Hui, Ho-Wah; Gong, Yuchuan; Qian, Feng; Yu, Lian.

Afiliação

Yu J; School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
Yao X; School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
Que C; Drug Product Development, Bristol Myers Squibb, 556 Morris Avenue, Summit, New Jersey 07901, United States.
Huang L; Drug Product Development, Bristol Myers Squibb, 556 Morris Avenue, Summit, New Jersey 07901, United States.
Hui HW; Drug Product Development, Bristol Myers Squibb, 556 Morris Avenue, Summit, New Jersey 07901, United States.
Gong Y; Drug Product Development, Bristol Myers Squibb, 556 Morris Avenue, Summit, New Jersey 07901, United States.
Qian F; Small Molecule CMC, BeiGene (Beijing) Co., Ltd., Beijing 102206, China.
Yu L; School of Pharmaceutical Sciences and Beijing Advanced Innovation Center for Structural Biology, Tsinghua University, Beijing 100084, China.

Mol Pharm ; 19(9): 3350-3357, 2022 09 05.

Article em En | MEDLINE | ID: mdl-35985030

Assuntos

Polímeros; Povidona; Vidro; Cinética; Polímeros/química; Povidona/química; Solubilidade

Palavras-chave

XPS; amorphous solid dispersion; polymer; surface concentration; surface enrichment kinetics

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polímeros / Povidona Tipo de estudo: Prognostic_studies Idioma: En Revista: Mol Pharm Assunto da revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

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