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Small extracellular vesicles: multi-faceted tools for leukemia immune evasion in vivo.
Gargiulo, Ernesto; Viry, Elodie; Moussay, Etienne; Paggetti, Jerome.
Afiliação
  • Gargiulo E; Tumor Stroma Interactions Group, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg.
  • Viry E; Department of Hematology, CLL Laboratory, Rigshospitalet, Copenhagen, Denmark.
  • Moussay E; PERSIMUNE, Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark.
  • Paggetti J; Tumor Stroma Interactions Group, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg.
Oncoimmunology ; 11(1): 2127507, 2022.
Article em En | MEDLINE | ID: mdl-36185808
ABSTRACT
Recently, small extracellular vesicles (sEVs) secreted in vivo from chronic lymphocytic leukemia (CLL) preclinical murine models were characterized. Leukemia microenvironment sEV (LME-sEVs) selectively target CD8+ T-cells, inducing exhaustion and hampering anti-tumor immune response. Additionally, a sEV-related gene expression correlated with patient treatment-free survival, overall survival and clinical parameters.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Linfocítica Crônica de Células B / Vesículas Extracelulares Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Oncoimmunology Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Luxemburgo
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Linfocítica Crônica de Células B / Vesículas Extracelulares Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Oncoimmunology Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Luxemburgo