Your browser doesn't support javascript.
loading
Beta-lactam allergies, surgical site infections, and prophylaxis in solid organ transplant recipients at a single center: A retrospective cohort study.
Mowrer, Clayton; Lyden, Elizabeth; Matthews, Stephen; Abbas, Anum; Bergman, Scott; Alexander, Bryan T; Van Schooneveld, Trevor C; Stohs, Erica J.
Afiliação
  • Mowrer C; Division of Infectious Diseases, Department of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
  • Lyden E; Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska, USA.
  • Matthews S; Infection Control and Epidemiology, Nebraska Medicine, Omaha, Nebraska, USA.
  • Abbas A; Division of Infectious Diseases, Department of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
  • Bergman S; Department of Pharmaceutical and Nutritional Care, Nebraska Medicine, Omaha, Nebraska, USA.
  • Alexander BT; Department of Pharmaceutical and Nutritional Care, Nebraska Medicine, Omaha, Nebraska, USA.
  • Van Schooneveld TC; Division of Infectious Diseases, Department of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
  • Stohs EJ; Division of Infectious Diseases, Department of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Transpl Infect Dis ; 24(5): e13907, 2022 Oct.
Article em En | MEDLINE | ID: mdl-36254522
ABSTRACT

BACKGROUND:

Beta-lactam allergies (BLAs) are common in hospitalized patients, including transplant recipients. BLA is associated with decreased use of preferred surgical site infection (SSI) prophylaxis and increased SSIs, but this has not been studied in the transplant population.

METHODS:

We reviewed adult heart, kidney, and liver transplant recipients between January 1, 2016 and December 31, 2019 to characterize reported BLA and collect SSI prophylaxis regimens at time of transplant. We compared the use of preferred SSI prophylaxis and SSI incidence based on reported BLA status. Post hoc we collected antibiotic days of therapy (DOT) (excluding pneumocystis prophylaxis) in the 30-day period posttransplant for patients without SSI. We utilized descriptive statistics for comparisons.

RESULTS:

Of 691 patients included (116 heart, 400 kidney, and 175 liver transplant recipients), 118 (17%) reported BLA. Rash and hives were the two most reported BLA reactions (36% and 24%), categorized as potential T-cell mediated and IgE mediated, respectively. Preferred SSI prophylaxis was prescribed in 13 (11%) patients with BLA and 573 (92%) without BLA (p < .001). No difference could be detected in SSI incidence between BLA and non-BLA patients (4.2 vs. 4.3%, p = 1.0). Of 659 without SSI, 169 (25.6%) received antibiotics within 30 days of transplant; mean antibiotic DOT for BLA and non-BLA patients were 3.5 ± 8.0 versus 2.3 ± 5.8, p = .12.

CONCLUSION:

BLA transplant recipients received nonpreferred SSI prophylaxis more frequently than non-BLA recipients, but there was no difference in 30-day SSIs between the groups. One-fourth of solid organ transplant recipients received systemic antibiotics within 30 days of transplant.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Órgãos / Hipersensibilidade Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Adult / Humans Idioma: En Revista: Transpl Infect Dis Assunto da revista: TRANSPLANTE Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Órgãos / Hipersensibilidade Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Adult / Humans Idioma: En Revista: Transpl Infect Dis Assunto da revista: TRANSPLANTE Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos