28-day repeated dose toxicity and toxicokinetics study on new melatonergic antidepressant GW117 in beagle dogs.

Gao, Mei; Chen, Kai; Gu, Wei; Liu, Xiaoyu; Liu, Tianbin; Ying, Yong; Cao, Chong; Zhang, Yanhua; Zhang, Daizhou; Yang, Guiwen

Gao, Mei; Chen, Kai; Gu, Wei; Liu, Xiaoyu; Liu, Tianbin; Ying, Yong; Cao, Chong; Zhang, Yanhua; Zhang, Daizhou; Yang, Guiwen.

Afiliação

Gao M; Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, Jinan, 250014, China.
Chen K; Shandong Academy of Pharmaceutical Sciences, Jinan, 250101, China.
Gu W; Shandong Academy of Pharmaceutical Sciences, Jinan, 250101, China.
Liu X; Beijing GreatWay Pharmaceutical Technology Co., Ltd., Beijing, 100850, China.
Liu T; Shandong Academy of Pharmaceutical Sciences, Jinan, 250101, China.
Ying Y; Shandong Academy of Pharmaceutical Sciences, Jinan, 250101, China.
Cao C; Shandong Academy of Pharmaceutical Sciences, Jinan, 250101, China.
Zhang Y; Shandong Academy of Pharmaceutical Sciences, Jinan, 250101, China.
Zhang D; Shandong Academy of Pharmaceutical Sciences, Jinan, 250101, China.
Yang G; Shandong Academy of Pharmaceutical Sciences, Jinan, 250101, China.

J Appl Toxicol ; 43(4): 577-588, 2023 04.

Article em En | MEDLINE | ID: mdl-36268681

Assuntos

Fígado; Masculino; Cães; Animais; Feminino; Toxicocinética; Nível de Efeito Adverso não Observado

Palavras-chave

GW117; NOAEL; beagle dogs; repeated dose toxicity; toxicokinetics

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fígado Limite: Animals Idioma: En Revista: J Appl Toxicol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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