The oldest unvaccinated Covid-19 survivors in South America.
Immun Ageing
; 19(1): 57, 2022 Nov 16.
Article
em En
| MEDLINE
| ID: mdl-36384671
ABSTRACT
BACKGROUND:
Although older adults are at a high risk of severe or critical Covid-19, there are many cases of unvaccinated centenarians who had a silent infection or recovered from mild or moderate Covid-19. We studied three Brazilian supercentenarians, older than 110 years, who survived Covid-19 in 2020 before being vaccinated.RESULTS:
Despite their advanced age, humoral immune response analysis showed that these individuals displayed robust levels of IgG and neutralizing antibodies (NAbs) against SARS-CoV-2. Enrichment of plasma proteins and metabolites related to innate immune response and host defense was also observed. None presented autoantibodies (auto-Abs) to type I interferon (IFN). Furthermore, these supercentenarians do not carry rare variants in genes underlying the known inborn errors of immunity, including particular inborn errors of type I IFN.CONCLUSION:
These observations suggest that their Covid-19 resilience might be a combination of their genetic background and their innate and adaptive immunity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Immun Ageing
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Brasil