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The Role of L-Arginine-NO System in Female Reproduction: A Narrative Review.
Bodis, Jozsef; Farkas, Balint; Nagy, Bernadett; Kovacs, Kalman; Sulyok, Endre.
Afiliação
  • Bodis J; Department of Obstetrics and Gynecology, University of Pecs School of Medicine, 7624 Pécs, Hungary.
  • Farkas B; MTA-PTE Human Reproduction Scientific Research Group, University of Pécs, 7624 Pécs, Hungary.
  • Nagy B; National Laboratory on Human Reproduction, University of Pécs, 7622 Pécs, Hungary.
  • Kovacs K; Department of Obstetrics and Gynecology, University of Pecs School of Medicine, 7624 Pécs, Hungary.
  • Sulyok E; MTA-PTE Human Reproduction Scientific Research Group, University of Pécs, 7624 Pécs, Hungary.
Int J Mol Sci ; 23(23)2022 Nov 28.
Article em En | MEDLINE | ID: mdl-36499238
Accumulating evidence are available on the involvement of l-arginine-nitric oxide (NO) system in complex biological processes and numerous clinical conditions. Particular attention was made to reveal the association of l-arginine and methylarginines to outcome measures of women undergoing in vitro fertilization (IVF). This review attempts to summarize the expression and function of the essential elements of this system with particular reference to the different stages of female reproduction. A literature search was performed on the PubMed and Google Scholar systems. Publications were selected for evaluation according to the results presented in the Abstract. The regulatory role of NO during the period of folliculogenesis, oocyte maturation, fertilization, embryogenesis, implantation, placentation, pregnancy, and delivery was surveyed. The major aspects of cellular l-arginine uptake via cationic amino acid transporters (CATs), arginine catabolism by nitric oxide synthases (NOSs) to NO and l-citrulline and by arginase to ornithine, and polyamines are presented. The importance of NOS inhibition by methylated arginines and the redox-sensitive elements of the process of NO generation are also shown. The l-arginine-NO system plays a crucial role in all stages of female reproduction. Insufficiently low or excessively high rates of NO generation may have adverse influences on IVF outcome.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arginina / Óxido Nítrico Limite: Female / Humans / Pregnancy Idioma: En Revista: Int J Mol Sci Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Hungria

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arginina / Óxido Nítrico Limite: Female / Humans / Pregnancy Idioma: En Revista: Int J Mol Sci Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Hungria