Dactylosporolides: Glycosylated Macrolides from Dactylosporangium fulvum.
J Nat Prod
; 85(12): 2714-2722, 2022 12 23.
Article
em En
| MEDLINE
| ID: mdl-36512509
ABSTRACT
A series of novel macrolides were discovered from the culture supernatant of the rare soil actinobacteria Dactylosporangium fulvum and named dactylosporolides A-C. The structure and absolute configuration of these dactylosporolides were defined using a combination of NMR structural elucidation and analysis of the dactylosporolide biosynthetic gene cluster. Together these data revealed dactylosporolides to be composed of a central 22-membered macrolactone with an internal hemiketal ring and a protruding ketide tail that were (poly)glycosylated at two distal parts. While bearing no antibiotic activity, these dactylosporolides displayed activity against Plasmodium falciparum 3D7.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Actinobacteria
/
Micromonosporaceae
Idioma:
En
Revista:
J Nat Prod
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
França