Chronic graft-versus-host disease. Part I: Epidemiology, pathogenesis, and clinical manifestations.
J Am Acad Dermatol
; 90(1): 1-16, 2024 01.
Article
em En
| MEDLINE
| ID: mdl-36572065
ABSTRACT
Chronic graft-versus-host disease is a major complication of allogeneic hematopoietic cell transplantation and a leading cause of long-term morbidity, nonrelapse mortality, and impaired health-related quality of life. The skin is commonly affected and presents heterogeneously, making the role of dermatologists critical in both diagnosis and treatment. In addition, new clinical classification and grading schemes inform treatment algorithms, which now include 3 U.S. Food and Drug Administration-approved therapies, and evolving transplant techniques are changing disease epidemiology. Part I reviews the epidemiology, pathogenesis, clinical manifestations, and diagnosis of chronic graft-versus-host disease. Part II discusses disease grading and therapeutic management.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transplante de Células-Tronco Hematopoéticas
/
Síndrome de Bronquiolite Obliterante
/
Doença Enxerto-Hospedeiro
Tipo de estudo:
Etiology_studies
/
Screening_studies
Limite:
Humans
Idioma:
En
Revista:
J Am Acad Dermatol
Ano de publicação:
2024
Tipo de documento:
Article