Conformational Sampling Deciphers the Chameleonic Properties of a VHL-Based Degrader.

Ermondi, Giuseppe; Jimenez, Diego Garcia; Rossi Sebastiano, Matteo; Kihlberg, Jan; Caron, Giulia

Ermondi, Giuseppe; Jimenez, Diego Garcia; Rossi Sebastiano, Matteo; Kihlberg, Jan; Caron, Giulia.

Afiliação

Ermondi G; Department of Molecular Biotechnology and Health Sciences, University of Torino, Quarello 15, 10135 Torino, Italy.
Jimenez DG; Department of Molecular Biotechnology and Health Sciences, University of Torino, Quarello 15, 10135 Torino, Italy.
Rossi Sebastiano M; Department of Molecular Biotechnology and Health Sciences, University of Torino, Quarello 15, 10135 Torino, Italy.
Kihlberg J; Department of Chemistry-BMC, Uppsala University, SE-75123 Uppsala, Sweden.
Caron G; Department of Molecular Biotechnology and Health Sciences, University of Torino, Quarello 15, 10135 Torino, Italy.

Pharmaceutics ; 15(1)2023 Jan 12.

Article em En | MEDLINE | ID: mdl-36678900

Palavras-chave

NMR; PROTAC; bRo5; conformational sampling; early drug discovery; molecular chameleon

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Pharmaceutics Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Itália

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