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Phytochemical composition, antimicrobial activities, and cholinesterase inhibitory properties of the lichen Usnea diffracta Vain.
Hao, Yi-Meng; Yan, Yuan-Cong; Zhang, Qing; Liu, Bing-Qian; Wu, Chang-Sheng; Wang, Li-Ning.
Afiliação
  • Hao YM; School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
  • Yan YC; School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
  • Zhang Q; School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
  • Liu BQ; School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
  • Wu CS; State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Shandong University, Qingdao, China.
  • Wang LN; School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Front Chem ; 10: 1063645, 2022.
Article em En | MEDLINE | ID: mdl-36688056
Lichens are important sources of versatile bioactive compounds. Two new dibenzofurans (1-2), a multi-substituted single benzene ring (3), and two organic acid compounds (4-5) along with 25 known compounds (6-30) were isolated from the lichen Usnea diffracta Vain. Their structures were identified by physicochemical properties and spectral analyses. Compounds 1-30 were tested for inhibitory activities against Staphylococcus aureus, Escherichia coli, and Candida albicans by the disk diffusion method and microdilution assay respectively. Compound 3 showed moderate inhibitory activities against S. aureus and E. coli with the inhibition zone (IZ) of 6.2 mm and 6.3 mm, respectively. Depside 10 exhibited good activity against S.aureus and C. albicans with 6.6 mm and 32 µg/ml, respectively. The acetylcholinesterase inhibitory activities of compounds 1, 2, and 6-8 with the characteristic dibenzofuran scaffold were evaluated var anti-AChE assay and a molecular docking study. Compound 2 could better inhibit AChE at the concentration of 0.3 µmol/ml with a value of 61.07 ± 0.85%. The molecular docking study also demonstrated that compound 2 had the strongest binding affinity among the five dibenzofurans, and the "-CDOCKER Energy" value was 14.4513 kcal/mol.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Front Chem Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Front Chem Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China