Miniature mass spectrometer-based point-of-care assay for measuring phosphatidylethanol in blood.

Pandey, Sangeeta; Hu, Yanyang; Anderson, Peter L; Kiser, Jennifer J; Cooks, R Graham

Pandey, Sangeeta; Hu, Yanyang; Anderson, Peter L; Kiser, Jennifer J; Cooks, R Graham.

Afiliação

Pandey S; Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA. cooks@purdue.edu.
Hu Y; Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA. cooks@purdue.edu.
Anderson PL; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO 80045, USA. jennifer.kiser@cuanschutz.edu.
Kiser JJ; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO 80045, USA. jennifer.kiser@cuanschutz.edu.
Cooks RG; Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA. cooks@purdue.edu.

Analyst ; 148(7): 1430-1436, 2023 Mar 27.

Article em En | MEDLINE | ID: mdl-36892479

ABSTRACT

ABSTRACT

We demonstrate proof-of-concept for point-of-care assessment of long-term alcohol consumption by measuring phosphatidylethanol in blood/dried blood spots with nano-electrospray ionization and MS/MS using a miniature mass spectrometer. 'Abstinence', 'moderate', and 'chronic' consumption could be distinguished rapidly for both sample types, and quantitative performance was obtained with blood (LoQ-100 ng mL-1).

Assuntos

Sistemas Automatizados de Assistência Junto ao Leito; Espectrometria de Massas em Tandem; Glicerofosfolipídeos; Consumo de Bebidas Alcoólicas; Biomarcadores

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistemas Automatizados de Assistência Junto ao Leito / Espectrometria de Massas em Tandem Idioma: En Revista: Analyst Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google