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Endoplasmic Reticulum Stress in Osteoarthritis: A Novel Perspective on the Pathogenesis and Treatment.
Wen, Zeqin; Sun, Qi; Shan, Yunhan; Xie, Wenqing; Ding, Yilan; Wang, Weiyang; Ye, Ruixi; Xiao, Wenfeng; Li, Yusheng.
Afiliação
  • Wen Z; 1Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.
  • Sun Q; 2Xiangya School of Medicine, Central South University, Changsha, China.
  • Shan Y; 4Department of Orthopaedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
  • Xie W; 2Xiangya School of Medicine, Central South University, Changsha, China.
  • Ding Y; 1Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.
  • Wang W; 3National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
  • Ye R; 2Xiangya School of Medicine, Central South University, Changsha, China.
  • Xiao W; 2Xiangya School of Medicine, Central South University, Changsha, China.
  • Li Y; 2Xiangya School of Medicine, Central South University, Changsha, China.
Aging Dis ; 14(2): 283-286, 2023 Apr 01.
Article em En | MEDLINE | ID: mdl-37008062
ABSTRACT
Osteoarthritis (OA), the most common degenerative joint disease, causes an enormous socioeconomic burden due to its disabling properties and high prevalence. Increasing evidence suggests that OA is a whole-joint disease involving cartilage degradation, synovitis, meniscal lesions, and subchondral bone remodeling. Endoplasmic reticulum (ER) stress is the accumulation of misfolded/unfolded proteins in the ER. Recent studies have found that ER stress is involved in the OA pathological changes by influencing the physiological function and survival of chondrocytes, fibroblast-like synoviocytes, synovial macrophages, meniscus cells, osteoblasts, osteoclasts, osteocytes, and bone marrow mesenchymal stem cells. Therefore, ER stress is an attractive and promising target for OA. However, although targeting ER stress has been proven to alleviate OA progression in vitro and in vivo, the treatments for OA remain in preclinical stage and require further investigation.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Risk_factors_studies Idioma: En Revista: Aging Dis Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Risk_factors_studies Idioma: En Revista: Aging Dis Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China