Clinical Characteristics Associated With Posttransplant Survival Among Adults 70 Years Old or Older Undergoing Liver Transplantation.
J Clin Gastroenterol
; 58(5): 516-521, 2024.
Article
em En
| MEDLINE
| ID: mdl-37279205
ABSTRACT
GOALS We sought to identify pre-liver transplantation (LT) characteristics among older adults associated with post-LT survival. BACKGROUND:
The proportion of older patients undergoing deceased-donor liver transplantation (DDLT) has increased over time. STUDY We analyzed adult DDLT recipients in the United Network for Organ Sharing registry from 2016 through 2020, excluding patients listed as status 1 or with a model of end-stage liver disease exceptions for hepatocellular carcinoma. Kaplan-Meier methods were used to estimate post-LT survival probabilities among older recipients (age ≥70 y). Associations between clinical covariates and post-LT mortality were assessed using Cox regressions.RESULTS:
Of 22,862 DDLT recipients, 897 (4%) were 70 years old or older. Compared with younger recipients, older recipients had worse overall survival ( P < 0.01) (1 y 88% vs 92%, 3 y 77% vs 86%, and 5 y 67% vs 78%). Among older adults, in univariate Cox regressions, dialysis [hazards ratio (HR) 1.96, 95% CI 1.38-2.77] and poor functional status [defined as Karnofsky Performance Score (KPS) <40] (HR 1.82, 95% CI 1.31-2.53) were each associated with mortality, remaining significant on multivariable Cox regressions. The effect of dialysis and KPS <40 at LT on post-LT survival (HR 2.67, 95% CI 1.77-4.01) was worse than the effects of either KPS <40 (HR 1.52, 95% CI 1.03-2.23) or dialysis alone (HR 1.44, 95% CI 0.62-3.36). Older recipients with KPS >40 without dialysis had comparable survival rates compared with younger recipients ( P = 0.30).CONCLUSIONS:
While older DDLT recipients had worse overall post-LT survival compared with younger recipients, favorable survival rates were observed among older adults who did not require dialysis and had poor functional status. Poor functional status and dialysis at LT may be useful to stratify older adults at higher risk for poor post-LT outcomes.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transplante de Fígado
/
Carcinoma Hepatocelular
/
Neoplasias Hepáticas
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Humans
Idioma:
En
Revista:
J Clin Gastroenterol
Ano de publicação:
2024
Tipo de documento:
Article