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Defective T-cell response to COVID-19 vaccination in acute myeloid leukaemia and myelodysplastic syndromes.
Loke, Justin; Upasani, Vinit; Gaskell, Charlotte; Fox, Sonia; Fletcher, Rachel; Thomas, Catherine; Hopkins, Louise; Kumari, Anita; Tang, Tina; Yafai, Emily; Boucher, Rebecca; Homer, Victoria; Toth, Arpad; Chan, Y L Tracey; Randall, Katie; Rider, Tom; O'Nions, Jenny; Drew, Victoria; Pillai, Arvind; Dungarwalla, Moez; Murray, Duncan; Khan, Anjum; Wandroo, Farooq; Moore, Sally; Krishnamurthy, Pramila; Huang, Ya-Wen Jessica; Knapper, Steve; Byrne, Jenny; Zhao, Rui; Craddock, Charles; Parry, Helen; Moss, Paul; Stanworth, Simon J; Lowe, David M.
Afiliação
  • Loke J; Centre for Clinical Haematology, Queen Elizabeth Hospital, Birmingham, UK.
  • Upasani V; CRUK Clinical Trials Unit, University of Birmingham, Birmingham, UK.
  • Gaskell C; Dana Farber Cancer Institute, Boston, Massachusetts, USA.
  • Fox S; University College London, London, UK.
  • Fletcher R; CRUK Clinical Trials Unit, University of Birmingham, Birmingham, UK.
  • Thomas C; CRUK Clinical Trials Unit, University of Birmingham, Birmingham, UK.
  • Hopkins L; CRUK Clinical Trials Unit, University of Birmingham, Birmingham, UK.
  • Kumari A; CRUK Clinical Trials Unit, University of Birmingham, Birmingham, UK.
  • Tang T; CRUK Clinical Trials Unit, University of Birmingham, Birmingham, UK.
  • Yafai E; CRUK Clinical Trials Unit, University of Birmingham, Birmingham, UK.
  • Boucher R; CRUK Clinical Trials Unit, University of Birmingham, Birmingham, UK.
  • Homer V; CRUK Clinical Trials Unit, University of Birmingham, Birmingham, UK.
  • Toth A; CRUK Clinical Trials Unit, University of Birmingham, Birmingham, UK.
  • Chan YLT; CRUK Clinical Trials Unit, University of Birmingham, Birmingham, UK.
  • Randall K; Clatterbridge Cancer Hospital, Liverpool, UK.
  • Rider T; Worcestershire Acute Hospitals, Worcester, UK.
  • O'Nions J; South Warwickshire University NHS Foundation Trust, Warwick, UK.
  • Drew V; Brighton and Sussex University Hospitals NHS Trust, Brighton, UK.
  • Pillai A; University College London Hospital, London, UK.
  • Dungarwalla M; Bradford Teaching Hospital, Bradford, UK.
  • Murray D; Countess of Chester Hospital, Chester, UK.
  • Khan A; Milton Keynes University Hospital, Milton Keynes, UK.
  • Wandroo F; University Hospitals Coventry, Coventry, UK.
  • Moore S; St James Hospital, Leeds, UK.
  • Krishnamurthy P; Sandwell and West Birmingham Hospitals NHS Trust, West Bromwich, UK.
  • Huang YJ; Royal United Hospital Bath NHS Foundation Trust, Bath, UK.
  • Knapper S; King's College Hospital, London, UK.
  • Byrne J; Wirral University Teaching Hospital, Wirral, UK.
  • Zhao R; Cardiff University School of Medicine, Cardiff, UK.
  • Craddock C; Nottingham University Hospitals Trust, Nottingham, UK.
  • Parry H; Torbay Hospital, Torquay, UK.
  • Moss P; Centre for Clinical Haematology, Queen Elizabeth Hospital, Birmingham, UK.
  • Stanworth SJ; CRUK Clinical Trials Unit, University of Birmingham, Birmingham, UK.
  • Lowe DM; Centre for Clinical Haematology, Queen Elizabeth Hospital, Birmingham, UK.
Br J Haematol ; 202(3): 498-503, 2023 08.
Article em En | MEDLINE | ID: mdl-37303189
Limited data exist on COVID-19 vaccination efficacy in patients with acute myeloid leukemia and myelodysplasia with excess blasts (AML/MDS-EB2). We report results from a prospective study, PACE (Patients with AML and COVID-19 Epidemiology). 93 patients provided samples post-vaccine 2 or 3 (PV2, PV3). Antibodies against SARS-COV-2 spike antigen were detectable in all samples. Neutralization of the omicron variant was poorer than ancestral variants but improved PV3. In contrast, adequate T-cell reactivity to SARS-COV-2 spike protein was seen in only 16/47 (34%) patients PV2 and 23/52 (44%) PV3. Using regression models, disease response (not in CR/Cri), and increasing age predicted poor T cell response.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndromes Mielodisplásicas / Leucemia Mieloide Aguda / COVID-19 Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Br J Haematol Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndromes Mielodisplásicas / Leucemia Mieloide Aguda / COVID-19 Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Br J Haematol Ano de publicação: 2023 Tipo de documento: Article