A Nonconserved Histidine Residue on KRAS Drives Paralog Selectivity of the KRASG12D Inhibitor MRTX1133.

Keats, Miles A; Han, John J W; Lee, Yeon-Hwa; Lee, Chih-Shia; Luo, Ji

Keats, Miles A; Han, John J W; Lee, Yeon-Hwa; Lee, Chih-Shia; Luo, Ji.

Afiliação

Keats MA; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Han JJW; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Lee YH; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Lee CS; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Luo J; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

Cancer Res ; 83(17): 2816-2823, 2023 09 01.

Article em En | MEDLINE | ID: mdl-37339170

Assuntos

Histidina; Proteínas Proto-Oncogênicas p21(ras); Humanos; Proteínas Proto-Oncogênicas p21(ras)/genética; Mutação; Linhagem Celular

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas p21(ras) / Histidina Limite: Humans Idioma: En Revista: Cancer Res Ano de publicação: 2023 Tipo de documento: Article

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