Repair of topoisomerase 1-induced DNA damage by tyrosyl-DNA phosphodiesterase 2 (TDP2) is dependent on its magnesium binding.

Shimizu, Naoto; Hamada, Yusaku; Morozumi, Ryosuke; Yamamoto, Junpei; Iwai, Shigenori; Sugiyama, Kei-Ichi; Ide, Hiroshi; Tsuda, Masataka

Shimizu, Naoto; Hamada, Yusaku; Morozumi, Ryosuke; Yamamoto, Junpei; Iwai, Shigenori; Sugiyama, Kei-Ichi; Ide, Hiroshi; Tsuda, Masataka.

Afiliação

Shimizu N; Program of Mathematical and Life Sciences, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan.
Hamada Y; Program of Biomedical Science, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan.
Morozumi R; Program of Biomedical Science, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan.
Yamamoto J; Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka, Japan.
Iwai S; Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka, Japan.
Sugiyama KI; Division of Genetics and Mutagenesis, National Institute of Health Sciences, Kawasaki, Kanagawa, Japan.
Ide H; Program of Mathematical and Life Sciences, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan. Electronic address: ideh@hiroshima-u.ac.jp.
Tsuda M; Program of Mathematical and Life Sciences, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan; Program of Biomedical Science, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan; Division of Genetics and Mutagen

J Biol Chem ; 299(8): 104988, 2023 08.

Article em En | MEDLINE | ID: mdl-37392847

Assuntos

Proteínas de Ligação a DNA; Magnésio; Proteínas de Ligação a DNA/genética; Proteínas de Ligação a DNA/metabolismo; Magnésio/metabolismo; Nucleosídeos; Diester Fosfórico Hidrolases/genética; Diester Fosfórico Hidrolases/metabolismo; Dano ao DNA; DNA Topoisomerases Tipo I/genética; DNA Topoisomerases Tipo I/metabolismo; Inibidores da Topoisomerase; Camptotecina/farmacologia; DNA Topoisomerases Tipo II/genética; DNA Topoisomerases Tipo II/metabolismo; DNA; Reparo do DNA

Palavras-chave

catalytic mechanism; divalent metal ion; topoisomerase 1 (TOP1); tyrosyl-DNA phosphodiesterase 1 (TDP1); tyrosyl-DNA phosphodiesterase 2 (TDP2)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Ligação a DNA / Magnésio Idioma: En Revista: J Biol Chem Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Japão

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