Metabolic Fingerprints of Effective Fluoxetine Treatment in the Prefrontal Cortex of Chronically Socially Isolated Rats: Marker Candidates and Predictive Metabolites.

Filipovic, Dragana; Inderhees, Julica; Korda, Alexandra; Tadic, Predrag; Schwaninger, Markus; Inta, Dragos; Borgwardt, Stefan

Filipovic, Dragana; Inderhees, Julica; Korda, Alexandra; Tadic, Predrag; Schwaninger, Markus; Inta, Dragos; Borgwardt, Stefan.

Afiliação

Filipovic D; Department of Molecular Biology and Endocrinology, "VINCA" Institute of Nuclear Sciences-National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia.
Inderhees J; Institute for Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism, University of Lübeck, 23562 Lübeck, Germany.
Korda A; German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg-Kiel-Lübeck, 20251 Hamburg, Germany.
Tadic P; Center of Brain Behavior and Metabolism, University of Lübeck, 23562 Lübeck, Germany.
Schwaninger M; Department of Psychiatry and Psychotherapy, Center of Brain Behavior and Metabolism, University of Lübeck, 23562 Lübeck, Germany.
Inta D; School of Electrical Engineering, University of Belgrade, 11000 Belgrade, Serbia.
Borgwardt S; Institute for Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism, University of Lübeck, 23562 Lübeck, Germany.

Int J Mol Sci ; 24(13)2023 Jun 30.

Article em En | MEDLINE | ID: mdl-37446133

Assuntos

Depressão; Fluoxetina; Isolamento Social; Animais; Ratos; Antidepressivos/farmacologia; Antidepressivos/uso terapêutico; Depressão/tratamento farmacológico; Depressão/metabolismo; Fluoxetina/farmacologia; Fluoxetina/uso terapêutico; Córtex Pré-Frontal/metabolismo; Resultado do Tratamento; Inositol/genética; Inositol/metabolismo; Regulação para Cima/efeitos dos fármacos; Biomarcadores/metabolismo; Acetilcarnitina/metabolismo; Análise Multivariada; Comportamento Animal/efeitos dos fármacos; Masculino

Palavras-chave

ROC curve; depressive-like behavior; fluoxetine; metabolomics; prefrontal cortex; support vector machine-linear kernel

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Isolamento Social / Fluoxetina / Depressão Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Int J Mol Sci Ano de publicação: 2023 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google