The application of organ-on-chip models for the prediction of human pharmacokinetic profiles during drug development.

Keuper-Navis, Marit; Walles, Markus; Poller, Birk; Myszczyszyn, Adam; van der Made, Thomas K; Donkers, Joanne; Eslami Amirabadi, Hossein; Wilmer, Martijn J; Aan, Saskia; Spee, Bart; Masereeuw, Rosalinde; van de Steeg, Evita

Keuper-Navis, Marit; Walles, Markus; Poller, Birk; Myszczyszyn, Adam; van der Made, Thomas K; Donkers, Joanne; Eslami Amirabadi, Hossein; Wilmer, Martijn J; Aan, Saskia; Spee, Bart; Masereeuw, Rosalinde; van de Steeg, Evita.

Afiliação

Keuper-Navis M; Department of Metabolic Health Research, Netherlands Organisation for Applied Scientific Research (TNO), Leiden, the Netherlands; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht, the Netherlands.
Walles M; Pharmacokinetic Sciences, Novartis Institutes for Biomedical Research, Basel, Switzerland.
Poller B; Pharmacokinetic Sciences, Novartis Institutes for Biomedical Research, Basel, Switzerland.
Myszczyszyn A; Faculty of Veterinary Medicine & Regenerative Medicine Center Utrecht (RMCU), Utrecht University, Utrecht, the Netherlands.
van der Made TK; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht, the Netherlands.
Donkers J; Department of Metabolic Health Research, Netherlands Organisation for Applied Scientific Research (TNO), Leiden, the Netherlands.
Eslami Amirabadi H; AZAR Innovations, Utrecht, the Netherlands.
Wilmer MJ; Cell4Pharma, Oss, the Netherlands.
Aan S; Stichting Proefdiervrij, Den Haag, the Netherlands.
Spee B; Faculty of Veterinary Medicine & Regenerative Medicine Center Utrecht (RMCU), Utrecht University, Utrecht, the Netherlands.
Masereeuw R; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht, the Netherlands.
van de Steeg E; Department of Metabolic Health Research, Netherlands Organisation for Applied Scientific Research (TNO), Leiden, the Netherlands. Electronic address: Evita.vandesteeg@tno.nl.

Pharmacol Res ; 195: 106853, 2023 09.

Article em En | MEDLINE | ID: mdl-37473876

Assuntos

Desenvolvimento de Medicamentos; Modelos Biológicos; Humanos; Disponibilidade Biológica; Sistemas Microfisiológicos

Palavras-chave

ADME; Drug development; Organ-on-chip; Pharmacokinetics

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desenvolvimento de Medicamentos / Modelos Biológicos Tipo de estudo: Guideline / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Pharmacol Res Assunto da revista: FARMACOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Holanda

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