Fibroblast Activation Protein-Targeted Photodynamic Therapy of Cancer-Associated Fibroblasts in Murine Models for Pancreatic Ductal Adenocarcinoma.

Dorst, Daphne N; Smeets, Esther M M; Klein, Christian; Frielink, Cathelijne; Geijs, Daan; Trajkovic-Arsic, Marija; Cheung, Phyllis F Y; Stommel, Martijn W J; Gotthardt, Martin; Siveke, Jens T; Aarntzen, Erik H J G; van Lith, Sanne A M

Dorst, Daphne N; Smeets, Esther M M; Klein, Christian; Frielink, Cathelijne; Geijs, Daan; Trajkovic-Arsic, Marija; Cheung, Phyllis F Y; Stommel, Martijn W J; Gotthardt, Martin; Siveke, Jens T; Aarntzen, Erik H J G; van Lith, Sanne A M.

Afiliação

Dorst DN; Department of Medical Imaging, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Smeets EMM; Department of Medical Imaging, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Klein C; Roche Pharma Research and Early Development, Innovation Center Zurich, 8952 Schlieren, Switzerland.
Frielink C; Department of Medical Imaging, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Geijs D; Department of Pathology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Trajkovic-Arsic M; Bridge Institute of Experimental Tumour Therapy, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, 47057 Essen, Germany.
Cheung PFY; Division of Solid Tumour Translational Oncology, German Cancer Consortium (DKTK Partner Site Essen) and German Cancer Research Center, DKFZ, 69120 Heidelberg, Germany.
Stommel MWJ; Bridge Institute of Experimental Tumour Therapy, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, 47057 Essen, Germany.
Gotthardt M; Division of Solid Tumour Translational Oncology, German Cancer Consortium (DKTK Partner Site Essen) and German Cancer Research Center, DKFZ, 69120 Heidelberg, Germany.
Siveke JT; Department of Surgery, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Aarntzen EHJG; Department of Medical Imaging, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
van Lith SAM; Bridge Institute of Experimental Tumour Therapy, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, 47057 Essen, Germany.

Mol Pharm ; 20(8): 4319-4330, 2023 08 07.

Article em En | MEDLINE | ID: mdl-37485886

Assuntos

Fibroblastos Associados a Câncer; Carcinoma Ductal Pancreático; Neoplasias Pancreáticas; Fotoquimioterapia; Camundongos; Animais; Serina Endopeptidases/metabolismo; Caspase 3/metabolismo; Distribuição Tecidual; Modelos Animais de Doenças; Neoplasias Pancreáticas/metabolismo; Carcinoma Ductal Pancreático/patologia; Fibroblastos/metabolismo; Anticorpos/metabolismo; Linhagem Celular Tumoral; Neoplasias Pancreáticas

Palavras-chave

cancer-associated fibroblast (CAF); fibroblast activation protein (FAP); pancreatic ductal adenocarcinoma (PDAC); syngeneic models; targeted photodynamic therapy (tPDT)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Fotoquimioterapia / Carcinoma Ductal Pancreático / Fibroblastos Associados a Câncer Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Mol Pharm Assunto da revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Holanda

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