Histone Deacetylase 3-Directed PROTACs Have Anti-inflammatory Potential by Blocking Polarization of M0-like into M1-like Macrophages.

Zhao, Chunlong; Chen, Shipeng; Chen, Deng; Río-Bergé, Clàudia; Zhang, Jianqiu; Van Der Wouden, Petra E; Daemen, Toos; Dekker, Frank J

Zhao, Chunlong; Chen, Shipeng; Chen, Deng; Río-Bergé, Clàudia; Zhang, Jianqiu; Van Der Wouden, Petra E; Daemen, Toos; Dekker, Frank J.

Afiliação

Zhao C; Department of Chemical and Pharmaceutical Biology, Groningen, Research Institute of Pharmacy (GRIP), University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands.
Chen S; Department of Medical Microbiology and Infection Prevention, Tumor Virology and Cancer Immunotherapy, University Medical Center Groningen, University of Groningen Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands.
Chen D; Department of Chemical and Pharmaceutical Biology, Groningen, Research Institute of Pharmacy (GRIP), University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands.
Río-Bergé C; Department of Medical Microbiology and Infection Prevention, Tumor Virology and Cancer Immunotherapy, University Medical Center Groningen, University of Groningen Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands.
Zhang J; Department of Chemical and Pharmaceutical Biology, Groningen, Research Institute of Pharmacy (GRIP), University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands.
Van Der Wouden PE; Department of Chemical and Pharmaceutical Biology, Groningen, Research Institute of Pharmacy (GRIP), University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands.
Daemen T; Department of Medical Microbiology and Infection Prevention, Tumor Virology and Cancer Immunotherapy, University Medical Center Groningen, University of Groningen Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands.
Dekker FJ; Department of Chemical and Pharmaceutical Biology, Groningen, Research Institute of Pharmacy (GRIP), University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands.

Angew Chem Int Ed Engl ; 62(42): e202310059, 2023 Oct 16.

Article em En | MEDLINE | ID: mdl-37638390

Palavras-chave

Drug Design; Histone Deacetylase 3 (HDAC3); Inflammation; Macrophage Polarization; Proteolysis Targeting Chimeras (PROTACs)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Angew Chem Int Ed Engl Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Holanda

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