Treatment of older patients with multiple sclerosis: Results of an International Delphi Survey.
Mult Scler J Exp Transl Clin
; 9(3): 20552173231198588, 2023.
Article
em En
| MEDLINE
| ID: mdl-37720692
ABSTRACT
Background:
People over age 50-55 have historically been excluded from randomized clinical trials for multiple sclerosis (MS). However, more than half of those living with an MS diagnosis are over 55.Objective:
Explore the unique considerations of treating older people with MS (PwMS) using an iterative and structured Delphi-based assessment to gather expert opinions.Methods:
Eight MS neurologists with an interest in older PwMS developed a 2-round survey. Survey respondents were qualified neurologists with ≥3 years' experience, personally responsible for treatment decisions, and treating ≥20 patients per month, of whom ≥10% were ≥50 years old. Consensus was defined as ≥75% agreement on questions with categorical responses or as a mean score ≥4 on questions with numerical responses.Results:
In Survey 1, 224 neurologists responded; 180 of these completed Survey 2. Limited consensus was reached with varying levels of agreement on several topics including identification and assessment of older patients; factors relating to treatment decisions including immunosenescence and comorbidities; considerations for high-efficacy treatments; de-escalation or discontinuation of treatment; effects of COVID-19; and unmet needs for treating this population.Conclusion:
The results of this Delphi process highlight the need for targeted studies to create guidance for the care of older PwMS.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Clinical_trials
/
Guideline
/
Prognostic_studies
/
Qualitative_research
Idioma:
En
Revista:
Mult Scler J Exp Transl Clin
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Alemanha