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Shotgun Kinetic Target-Guided Synthesis Approach Enables the Discovery of Small-Molecule Inhibitors against Pathogenic Free-Living Amoeba Glucokinases.
Kassu, Mintesinot; Parvatkar, Prakash T; Milanes, Jillian; Monaghan, Neil P; Kim, Chungsik; Dowgiallo, Matthew; Zhao, Yingzhao; Asakawa, Ami H; Huang, Lili; Wagner, Alicia; Miller, Brandon; Carter, Karissa; Barrett, Kayleigh F; Tillery, Logan M; Barrett, Lynn K; Phan, Isabelle Q; Subramanian, Sandhya; Myler, Peter J; Van Voorhis, Wesley C; Leahy, James W; Rice, Christopher A; Kyle, Dennis E; Morris, James; Manetsch, Roman.
Afiliação
  • Kassu M; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
  • Parvatkar PT; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
  • Milanes J; Eukaryotic Pathogens Innovation Center, Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina 29634, United States.
  • Monaghan NP; Eukaryotic Pathogens Innovation Center, Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina 29634, United States.
  • Kim C; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
  • Dowgiallo M; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
  • Zhao Y; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
  • Asakawa AH; Department of Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts 02115, United States.
  • Huang L; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
  • Wagner A; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
  • Miller B; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
  • Carter K; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
  • Barrett KF; Center for Emerging and Re-emerging Infectious Diseases (CERID), Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98109, United States.
  • Tillery LM; Center for Emerging and Re-emerging Infectious Diseases (CERID), Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98109, United States.
  • Barrett LK; Center for Emerging and Re-emerging Infectious Diseases (CERID), Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98109, United States.
  • Phan IQ; Center for Global Infectious Diseases Research, Seattle Children's Research Center, Seattle, Washington 98109, United States.
  • Subramanian S; Center for Global Infectious Diseases Research, Seattle Children's Research Center, Seattle, Washington 98109, United States.
  • Myler PJ; Center for Global Infectious Diseases Research, Seattle Children's Research Center, Seattle, Washington 98109, United States.
  • Van Voorhis WC; Center for Emerging and Re-emerging Infectious Diseases (CERID), Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98109, United States.
  • Leahy JW; Department of Chemistry, University of South Florida, Tampa, Florida 33620, United States.
  • Rice CA; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907, United States.
  • Kyle DE; Purdue Institute for Drug Discovery (PIDD), Purdue University, West Lafayette, Indiana 47907, United States.
  • Morris J; Purdue Institute of Inflammation, Immunology and Infectious Disease (PI4D), Purdue University, West Lafayette, Indiana 47907, United States.
  • Manetsch R; Department of Cellular Biology, University of Georgia, Athens, Georgia 30602, United States.
ACS Infect Dis ; 9(11): 2190-2201, 2023 11 10.
Article em En | MEDLINE | ID: mdl-37820055
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Naegleria fowleri / Acanthamoeba castellanii / Balamuthia mandrillaris / Amoeba Limite: Humans Idioma: En Revista: ACS Infect Dis Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Naegleria fowleri / Acanthamoeba castellanii / Balamuthia mandrillaris / Amoeba Limite: Humans Idioma: En Revista: ACS Infect Dis Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos