Activation of the PERK-CHOP signaling pathway during endoplasmic reticulum stress contributes to olanzapine-induced dyslipidemia.

Liu, Lu; Tang, Lei; Luo, Jia-Ming; Chen, Si-Yu; Yi, Chun-Yan; Liu, Xue-Mei; Hu, Chang-Hua

Liu, Lu; Tang, Lei; Luo, Jia-Ming; Chen, Si-Yu; Yi, Chun-Yan; Liu, Xue-Mei; Hu, Chang-Hua.

Afiliação

Liu L; School of Pharmaceutical Sciences, Medical Research Institute, Southwest University, Chongqing, 400715, China.
Tang L; NMPA Key Laboratory for Quality Monitoring of Narcotic Drugs and Psychotropic Substances, Chongqing, 400715, China.
Luo JM; School of Mental Health, North Sichuan Medical College, Nanchong, 637100, China.
Chen SY; School of Mental Health, North Sichuan Medical College, Nanchong, 637100, China.
Yi CY; Mental Health Center, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637100, China.
Liu XM; School of Mental Health, North Sichuan Medical College, Nanchong, 637100, China.
Hu CH; Mental Health Center, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637100, China.

Acta Pharmacol Sin ; 45(3): 502-516, 2024 Mar.

Article em En | MEDLINE | ID: mdl-37880338

Assuntos

Dislipidemias; Transdução de Sinais; Humanos; Olanzapina/farmacologia; Estudos de Casos e Controles; Estresse do Retículo Endoplasmático; Dislipidemias/induzido quimicamente; Lipídeos; eIF-2 Quinase/metabolismo; Apoptose

Palavras-chave

PERK-CHOP signaling pathway; SREBPs; antipsychotic drug; endoplasmic reticulum stress; lipid metabolism disorder; olanzapine

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Dislipidemias Limite: Humans Idioma: En Revista: Acta Pharmacol Sin Assunto da revista: FARMACOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

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