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Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3Kα Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia.
Varkaris, Andreas; Pazolli, Ermira; Gunaydin, Hakan; Wang, Qi; Pierce, Levi; Boezio, Alessandro A; Bulku, Artemisa; DiPietro, Lucian; Fridrich, Cary; Frost, Adam; Giordanetto, Fabrizio; Hamilton, Erika P; Harris, Katherine; Holliday, Michael; Hunter, Tamieka L; Iskandar, Amanda; Ji, Yongli; Larivée, Alexandre; LaRochelle, Jonathan R; Lescarbeau, André; Llambi, Fabien; Lormil, Brenda; Mader, Mary M; Mar, Brenton G; Martin, Iain; McLean, Thomas H; Michelsen, Klaus; Pechersky, Yakov; Puente-Poushnejad, Erika; Raynor, Kevin; Rogala, Dipali; Samadani, Ramin; Schram, Alison M; Shortsleeves, Kelley; Swaminathan, Sweta; Tajmir, Shahein; Tan, Gege; Tang, Yong; Valverde, Roberto; Wehrenberg, Bryan; Wilbur, Jeremy; Williams, Bret R; Zeng, Hongtao; Zhang, Hanmo; Walters, W Patrick; Wolf, Beni B; Shaw, David E; Bergstrom, Donald A; Watters, James; Fraser, James S.
Afiliação
  • Varkaris A; Mass General Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts.
  • Pazolli E; Relay Therapeutics, Inc., Cambridge, Massachusetts.
  • Gunaydin H; Relay Therapeutics, Inc., Cambridge, Massachusetts.
  • Wang Q; D. E. Shaw Research, New York, New York.
  • Pierce L; Relay Therapeutics, Inc., Cambridge, Massachusetts.
  • Boezio AA; Relay Therapeutics, Inc., Cambridge, Massachusetts.
  • Bulku A; Relay Therapeutics, Inc., Cambridge, Massachusetts.
  • DiPietro L; Relay Therapeutics, Inc., Cambridge, Massachusetts.
  • Fridrich C; Relay Therapeutics, Inc., Cambridge, Massachusetts.
  • Frost A; Altos Labs, Institute of Science, San Francisco, California.
  • Giordanetto F; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California.
  • Hamilton EP; California Institute of Quantitative Biosciences (QB3), University of California San Francisco, San Francisco, California.
  • Harris K; D. E. Shaw Research, New York, New York.
  • Holliday M; Sarah Cannon Research Institute/Tennessee Oncology, Nashville, Tennessee.
  • Hunter TL; MGH/Mass General Cancer Center at Danvers, Danvers, Massachusetts.
  • Iskandar A; Relay Therapeutics, Inc., Cambridge, Massachusetts.
  • Ji Y; Relay Therapeutics, Inc., Cambridge, Massachusetts.
  • Larivée A; Relay Therapeutics, Inc., Cambridge, Massachusetts.
  • LaRochelle JR; Hematology/Oncology, Exeter Hospital, Exeter, New Hampshire.
  • Lescarbeau A; Paraza Pharma, Inc. Montreal, Canada.
  • Llambi F; Relay Therapeutics, Inc., Cambridge, Massachusetts.
  • Lormil B; Relay Therapeutics, Inc., Cambridge, Massachusetts.
  • Mader MM; Relay Therapeutics, Inc., Cambridge, Massachusetts.
  • Mar BG; Mass General Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts.
  • Martin I; Relay Therapeutics, Inc., Cambridge, Massachusetts.
  • McLean TH; Relay Therapeutics, Inc., Cambridge, Massachusetts.
  • Michelsen K; Relay Therapeutics, Inc., Cambridge, Massachusetts.
  • Pechersky Y; Relay Therapeutics, Inc., Cambridge, Massachusetts.
  • Puente-Poushnejad E; Relay Therapeutics, Inc., Cambridge, Massachusetts.
  • Raynor K; D. E. Shaw Research, New York, New York.
  • Rogala D; Relay Therapeutics, Inc., Cambridge, Massachusetts.
  • Samadani R; Relay Therapeutics, Inc., Cambridge, Massachusetts.
  • Schram AM; Relay Therapeutics, Inc., Cambridge, Massachusetts.
  • Shortsleeves K; Relay Therapeutics, Inc., Cambridge, Massachusetts.
  • Swaminathan S; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Tajmir S; Relay Therapeutics, Inc., Cambridge, Massachusetts.
  • Tan G; Relay Therapeutics, Inc., Cambridge, Massachusetts.
  • Tang Y; MGH Radiology, Harvard Medical School, Boston, Massachusetts.
  • Valverde R; Relay Therapeutics, Inc., Cambridge, Massachusetts.
  • Wehrenberg B; Relay Therapeutics, Inc., Cambridge, Massachusetts.
  • Wilbur J; Relay Therapeutics, Inc., Cambridge, Massachusetts.
  • Williams BR; Relay Therapeutics, Inc., Cambridge, Massachusetts.
  • Zeng H; Relay Therapeutics, Inc., Cambridge, Massachusetts.
  • Zhang H; Relay Therapeutics, Inc., Cambridge, Massachusetts.
  • Walters WP; Relay Therapeutics, Inc., Cambridge, Massachusetts.
  • Wolf BB; Relay Therapeutics, Inc., Cambridge, Massachusetts.
  • Shaw DE; Mass General Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts.
  • Bergstrom DA; Relay Therapeutics, Inc., Cambridge, Massachusetts.
  • Watters J; D. E. Shaw Research, New York, New York.
  • Fraser JS; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York.
Cancer Discov ; 14(2): 240-257, 2024 Feb 08.
Article em En | MEDLINE | ID: mdl-37916956
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Hiperinsulinismo Limite: Female / Humans Idioma: En Revista: Cancer Discov Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Hiperinsulinismo Limite: Female / Humans Idioma: En Revista: Cancer Discov Ano de publicação: 2024 Tipo de documento: Article