RTA 408 ameliorates diabetic cardiomyopathy by activating Nrf2 to regulate mitochondrial fission and fusion and inhibiting NF-&#954;B-mediated inflammation.

Hao, Jinjin; Zhou, Jiedong; Hu, Songqing; Zhang, Peipei; Wu, Haowei; Yang, Juntao; Zhao, Bingjie; Liu, Hanxuan; Lin, Hui; Chi, Jufang; Lou, Dajun

RTA 408 ameliorates diabetic cardiomyopathy by activating Nrf2 to regulate mitochondrial fission and fusion and inhibiting NF-κB-mediated inflammation.

Hao, Jinjin; Zhou, Jiedong; Hu, Songqing; Zhang, Peipei; Wu, Haowei; Yang, Juntao; Zhao, Bingjie; Liu, Hanxuan; Lin, Hui; Chi, Jufang; Lou, Dajun.

Afiliação

Hao J; Department of Endocrinology, Shaoxing People's Hospital, Shaoxing, China.
Zhou J; College of Medicine, Shaoxing University, Shaoxing, China.
Hu S; Zhejiang University School of Medicine, Hangzhou, China.
Zhang P; Zhejiang Chinese Medical University, Hangzhou, China.
Wu H; Zhejiang University School of Medicine, Hangzhou, China.
Yang J; College of Medicine, Shaoxing University, Shaoxing, China.
Zhao B; College of Medicine, Shaoxing University, Shaoxing, China.
Liu H; College of Medicine, Shaoxing University, Shaoxing, China.
Lin H; The Affiliated Lihuili Hospital of Ningbo University, Ningbo, China.
Chi J; Department of Cardiology, Zhuji People's Hospital, Shaoxing, China.
Lou D; Department of Endocrinology, Shaoxing People's Hospital, Shaoxing, China.

Am J Physiol Cell Physiol ; 326(2): C331-C347, 2024 Feb 01.

Article em En | MEDLINE | ID: mdl-38047307

Assuntos

Diabetes Mellitus; Cardiomiopatias Diabéticas; Triterpenos; Camundongos; Animais; NF-kappa B/genética; Cardiomiopatias Diabéticas/tratamento farmacológico; Cardiomiopatias Diabéticas/genética; Cardiomiopatias Diabéticas/metabolismo; Fator 2 Relacionado a NF-E2/genética; Fator 2 Relacionado a NF-E2/metabolismo; Dinâmica Mitocondrial; Estresse Oxidativo; Inflamação/metabolismo; Triterpenos/metabolismo; Triterpenos/farmacologia; Triterpenos/uso terapêutico; Miócitos Cardíacos/metabolismo; Glucose/metabolismo; Diabetes Mellitus/metabolismo

Palavras-chave

Nrf2; RTA 408; diabetic cardiomyopathy; mitochondrial fission and fusion; oxidative stress

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triterpenos / Diabetes Mellitus / Cardiomiopatias Diabéticas Limite: Animals Idioma: En Revista: Am J Physiol Cell Physiol Assunto da revista: FISIOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google