Directed evolution of Baeyer-Villiger monooxygenase for highly secretory expressed in Pichia pastoris and efficient preparation of chiral pyrazole sulfoxide.

Qin, Peng; Lu, Xin-Yi; Xu, Jian-He; Yu, Hui-Lei

Qin, Peng; Lu, Xin-Yi; Xu, Jian-He; Yu, Hui-Lei.

Afiliação

Qin P; State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Centre for Biomanufacturing, East China University of Science and Technology, Shanghai, China.
Lu XY; State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Centre for Biomanufacturing, East China University of Science and Technology, Shanghai, China.
Xu JH; State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Centre for Biomanufacturing, East China University of Science and Technology, Shanghai, China.
Yu HL; State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Centre for Biomanufacturing, East China University of Science and Technology, Shanghai, China.

Biotechnol Bioeng ; 121(3): 971-979, 2024 Mar.

Article em En | MEDLINE | ID: mdl-38088450

Assuntos

Oxigenases de Função Mista; Pichia; Saccharomycetales; Oxigenases de Função Mista/metabolismo; Pichia/genética; Pichia/metabolismo; Proteínas Recombinantes/metabolismo; Sulfóxidos/metabolismo; Sulfetos/metabolismo

Palavras-chave

(S)-omeprazole; Baeyer-Villiger monooxygenase; Pichia pastoris; directed evolution; high-throughput screening; protein expression

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pichia / Saccharomycetales / Oxigenases de Função Mista Idioma: En Revista: Biotechnol Bioeng Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

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