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Increased production of inflammatory cytokines by circulating monocytes in mesial temporal lobe epilepsy: A possible role in drug resistance.
Milano, C; Montali, M; Barachini, S; Burzi, I S; Pratesi, F; Petrozzi, L; Chico, L; Morganti, R; Gambino, G; Rossi, L; Ceravolo, R; Siciliano, G; Migliorini, P; Petrini, I; Pizzanelli, C.
Afiliação
  • Milano C; Department of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Pisa, Italy. Electronic address: chiara.milano@phd.unipi.it.
  • Montali M; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
  • Barachini S; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
  • Burzi IS; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
  • Pratesi F; Department of Translational Research and New Technology in Medicine and Surgery, University of Pisa, Pisa, Italy.
  • Petrozzi L; Department of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Pisa, Italy.
  • Chico L; Department of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Pisa, Italy.
  • Morganti R; Section of Statistics, University of Pisa, Pisa, Italy.
  • Gambino G; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
  • Rossi L; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
  • Ceravolo R; Department of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Pisa, Italy.
  • Siciliano G; Department of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Pisa, Italy.
  • Migliorini P; Department of Clinical and Experimental Medicine, Clinical Immunology and Allergy Unit, University of Pisa, Pisa, Italy.
  • Petrini I; Department of Translational Research and New Technology in Medicine and Surgery, University of Pisa, Pisa, Italy.
  • Pizzanelli C; Department of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Pisa, Italy. Electronic address: c.pizzanelli@ao-pisa.toscana.it.
J Neuroimmunol ; 386: 578272, 2024 01 15.
Article em En | MEDLINE | ID: mdl-38160122
ABSTRACT
We analyzed peripheral blood mononuclear cells (PBMCs) and serum inflammatory biomarkers in patients with mesial temporal lobe epilepsy (drug-resistant - DR, vs. drug-sensitive - DS). Patients with epilepsy showed higher levels of serum CCL2, CCL3, IL-8 and AOPP, and lower levels of FRAP and thiols compared to healthy controls (HC). Although none of the serum biomarkers distinguished DR from DS patients, when analysing intracellular cytokines after in vitro stimulation, DR patients presented higher percentages of IL-1ß and IL-6 positive monocytes compared to DS patients and HC. Circulating innate immune cells might be implicated in DR epilepsy and constitute potential new targets for treatments.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Epilepsia / Epilepsia do Lobo Temporal Limite: Humans Idioma: En Revista: J Neuroimmunol Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Epilepsia / Epilepsia do Lobo Temporal Limite: Humans Idioma: En Revista: J Neuroimmunol Ano de publicação: 2024 Tipo de documento: Article