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Childhood-onset systemic lupus erythematosus (cSLE) and malignancy: a nationwide multicentre series review.
Brufatto, Matheus Zanata; Lanças, Sean Hideo Shirata; de Albuquerque Pedrosa Fernandes, Taciana; Sallum, Adriana Maluf Elias; Campos, Lucia Maria Arruda; Sakamoto, Ana Paula; Terreri, Maria Teresa; Sztajnbok, Flavio Roberto; Bica, Blanca Elena Rios Gomes; Ferriani, Virginia Paes Leme; de Carvalho, Luciana Martins; Silva, Clovis Artur Almeida; Saad-Magalhaes, Claudia.
Afiliação
  • Brufatto MZ; Department of Internal Medicine, Discipline of Rheumatology, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil. mz.brufatto@unesp.br.
  • Lanças SHS; Department of Internal Medicine, Discipline of Rheumatology, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.
  • de Albuquerque Pedrosa Fernandes T; Department of Pediatrics, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.
  • Sallum AME; Pediatric Rheumatology Unit, Child and Adolescent Institute, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • Campos LMA; Pediatric Rheumatology Unit, Child and Adolescent Institute, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • Sakamoto AP; Pediatric Rheumatology Unit, Universidade Federal de São Paulo, São Paulo, Brazil.
  • Terreri MT; Pediatric Rheumatology Unit, Universidade Federal de São Paulo, São Paulo, Brazil.
  • Sztajnbok FR; Pediatric Rheumatology Unit, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
  • Bica BERG; Pediatric Rheumatology Unit, Universidade Federal do Rio de Janeiro, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil.
  • Ferriani VPL; Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
  • de Carvalho LM; Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
  • Silva CAA; Adolescent and Pediatric Rheumatology Units, Child and Adolescent Institute HC-FMUSP, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil.
  • Saad-Magalhaes C; Pediatric Rheumatology Unit, Department of Pathology, Botucatu Medical School, Sao Paulo State University (UNESP), Botucatu, São Paulo, Brazil.
Adv Rheumatol ; 64(1): 13, 2024 02 06.
Article em En | MEDLINE | ID: mdl-38321580
ABSTRACT

BACKGROUND:

Increased malignancy frequency is well documented in adult-systemic lupus erythematosus (SLE), but with limited reports in childhood-onset SLE (cSLE) series. We explored the frequency of malignancy associated with cSLE, describing clinical and demographic characteristics, disease activity and cumulative damage, by the time of malignancy diagnosis.

METHOD:

A retrospective case-notes review, in a nationwide cohort from 27 Pediatric Rheumatology centres, with descriptive biopsy-proven malignancy, disease activity/damage accrual, and immunosuppressive treatment were compiled in each participating centre, using a standard protocol.

RESULTS:

Of the 1757 cSLE cases in the updated cohort, 12 (0.7%) developed malignancy with median time 10 years after cSLE diagnosis. There were 91% females, median age at cSLE diagnosis 12 years, median age at malignancy diagnosis 23 years. Of all diagnosed malignancies, 11 were single-site, and a single case with concomitant multiple sites; four had haematological (0.22%) and 8 solid malignancy (0.45%). Median (min-max) SLEDAI-2 K scores were 9 (0-38), median (min-max) SLICC/ACR-DI (SDI) score were 1 (1-5) Histopathology defined 1 Hodgkin's lymphoma, 2 non-Hodgkin's lymphoma, 1 acute lymphoblastic leukaemia; 4 gastrointestinal carcinoma, 1 squamous cell carcinoma of the tongue and 1 anal carcinoma; 1 had sigmoid adenocarcinoma and 1 stomach carcinoid; 3 had genital malignancy, being 1 vulvae, 1 cervix and 1 vulvae and cervix carcinomas; 1 had central nervous system oligodendroglioma; and 1 testicle germ cell teratoma.

CONCLUSION:

Estimated malignancy frequency of 0.7% was reported during cSLE follow up in a multicentric series. Median disease activity and cumulative damage scores, by the time of malignancy diagnoses, were high; considering that reported in adult series.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma / Lúpus Eritematoso Sistêmico Tipo de estudo: Guideline / Observational_studies / Risk_factors_studies Limite: Adult / Child / Female / Humans / Male Idioma: En Revista: Adv Rheumatol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma / Lúpus Eritematoso Sistêmico Tipo de estudo: Guideline / Observational_studies / Risk_factors_studies Limite: Adult / Child / Female / Humans / Male Idioma: En Revista: Adv Rheumatol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil